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TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM
Year:
1999
Source of publication :
genomics (source)
Authors :
סרוסי, אייל
;
.
Volume :
57
Co-Authors:
Seroussi, E., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Kedra, D., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Kost-Alimova, M., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden, Engelhardt Inst. of Molec. Biology, Russian Academy of Sciences, Vavilov Street 32, 117984 Moscow, Russian Federation
Sandberg-Nordqvist, A.-C., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Fransson, I., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Jacobs, J.F.M., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Fu, Y., Dept. of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States
Pan, H.-Q., Dept. of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States
Roe, B.A., Dept. of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States
Imreh, S., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Dumanski, J.P., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Facilitators :
From page:
380
To page:
388
(
Total pages:
9
)
Abstract:
The avian tom1 (target of myb 1) gene has been previously characterized from v-myb-transformed cells. We report here cloning of the human and mouse tom1 orthologs. Both genes are expressed ubiquitously, with the highest levels in skeletal muscle, brain, and intestines, as assessed by Northern blot and mRNA in situ hybridization. The N-terminal domain of the TOM1 protein shares similarity with HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (signal-transducing adaptor molecule), which are associated with vesicular trafficking at the endosome. A putative coiled-coil domain was also detected in the central part of the TOM1 protein. This domain structure suggests that TOM1 is another member of a family of genes implicated in the trafficking regulation of growth-factor-receptor complexes that are destined for degradation in the lysosome. We also show that a human paralog of TOM1 (TOM1-like gene 1) exists. Furthermore, we provide a transcription map over a 190-kb contig of the TOM1 region. This map includes its distal neighbors HMOX1 and MCM5 and two proximal novel genes, one of which is a HMG-box-containing gene (HMG2L1), and the other of unknown function. Using a genomic PAC clone, we demonstrate that the mouse Tom1 and Hmox1 genes are part of an as yet undescribed syntenic group between mouse chromosome 8C1 and human chromosome 22q13.1.
Note:
Related Files :
Animals
chromosome mapping
gene expression
gene mapping
mice
Phosphoproteins
proteins
עוד תגיות
תוכן קשור
More details
DOI :
10.1006/geno.1998.5739
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
29497
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:47
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Scientific Publication
TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM
57
Seroussi, E., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Kedra, D., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Kost-Alimova, M., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden, Engelhardt Inst. of Molec. Biology, Russian Academy of Sciences, Vavilov Street 32, 117984 Moscow, Russian Federation
Sandberg-Nordqvist, A.-C., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Fransson, I., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Jacobs, J.F.M., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
Fu, Y., Dept. of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States
Pan, H.-Q., Dept. of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States
Roe, B.A., Dept. of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States
Imreh, S., Microbiol. and Tum. Biol. Ctr. (MTC), Karolinska Institutet, S-171 77 Stockholm, Sweden
Dumanski, J.P., Department of Molecular Medicine, CMM Building, L8:00, Karolinska Hospital, S-171 76 Stockholm, Sweden
TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM
The avian tom1 (target of myb 1) gene has been previously characterized from v-myb-transformed cells. We report here cloning of the human and mouse tom1 orthologs. Both genes are expressed ubiquitously, with the highest levels in skeletal muscle, brain, and intestines, as assessed by Northern blot and mRNA in situ hybridization. The N-terminal domain of the TOM1 protein shares similarity with HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (signal-transducing adaptor molecule), which are associated with vesicular trafficking at the endosome. A putative coiled-coil domain was also detected in the central part of the TOM1 protein. This domain structure suggests that TOM1 is another member of a family of genes implicated in the trafficking regulation of growth-factor-receptor complexes that are destined for degradation in the lysosome. We also show that a human paralog of TOM1 (TOM1-like gene 1) exists. Furthermore, we provide a transcription map over a 190-kb contig of the TOM1 region. This map includes its distal neighbors HMOX1 and MCM5 and two proximal novel genes, one of which is a HMG-box-containing gene (HMG2L1), and the other of unknown function. Using a genomic PAC clone, we demonstrate that the mouse Tom1 and Hmox1 genes are part of an as yet undescribed syntenic group between mouse chromosome 8C1 and human chromosome 22q13.1.
Scientific Publication
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