חיפוש מתקדם
Planta Medica
Dudai, N., Hazeva Research and Development Center, Jacob Blaustein Institute for Desert Research, Ben Gurion University of the Negev, Beer Sheva, Israel
Weinstein, Y., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Krup, M., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Rabinski, T., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Ofir, R., Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel

Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investigated the anti-cancer potential of citral and its mode of action. Concentrations of 44.5 μM, comparable to the concentration of citral in a cup of tea prepared from 1 g of lemon grass, induced apoptosis in several hematopoietic cancer cell lines. Apoptosis was accompanied by DNA fragmentation and caspase-3 catalytic activity induction. Citral activity (22.25 μM) was compared to a reference compound like staurosporine (0.7 μM), in respect to DNA fragmentation and caspase-3 enzymatic activity. The apoptotic effect of citral depended on the α,β-unsaturated aldehyde group. © Georg Thieme Verlag KG Stuttgart.

פותח על ידי קלירמאש פתרונות בע"מ -
הספר "אוצר וולקני"
אודות
תנאי שימוש
Citral is a new inducer of caspase-3 in tumor cell lines
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Dudai, N., Hazeva Research and Development Center, Jacob Blaustein Institute for Desert Research, Ben Gurion University of the Negev, Beer Sheva, Israel
Weinstein, Y., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Krup, M., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Rabinski, T., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Ofir, R., Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
Citral is a new inducer of caspase-3 in tumor cell lines

Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investigated the anti-cancer potential of citral and its mode of action. Concentrations of 44.5 μM, comparable to the concentration of citral in a cup of tea prepared from 1 g of lemon grass, induced apoptosis in several hematopoietic cancer cell lines. Apoptosis was accompanied by DNA fragmentation and caspase-3 catalytic activity induction. Citral activity (22.25 μM) was compared to a reference compound like staurosporine (0.7 μM), in respect to DNA fragmentation and caspase-3 enzymatic activity. The apoptotic effect of citral depended on the α,β-unsaturated aldehyde group. © Georg Thieme Verlag KG Stuttgart.

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