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פותח על ידי קלירמאש פתרונות בע"מ -
Citral is a new inducer of caspase-3 in tumor cell lines
Year:
2005
Source of publication :
Planta Medica
Authors :
דודאי, נתיב
;
.
ויינשטיין, יעקב
;
.
קרופ, מרגלית
;
.
רבינסקי, טטיאנה
;
.
Volume :
71
Co-Authors:
Dudai, N., Hazeva Research and Development Center, Jacob Blaustein Institute for Desert Research, Ben Gurion University of the Negev, Beer Sheva, Israel
Weinstein, Y., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Krup, M., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Rabinski, T., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Ofir, R., Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
Facilitators :
From page:
484
To page:
488
(
Total pages:
5
)
Abstract:

Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investigated the anti-cancer potential of citral and its mode of action. Concentrations of 44.5 μM, comparable to the concentration of citral in a cup of tea prepared from 1 g of lemon grass, induced apoptosis in several hematopoietic cancer cell lines. Apoptosis was accompanied by DNA fragmentation and caspase-3 catalytic activity induction. Citral activity (22.25 μM) was compared to a reference compound like staurosporine (0.7 μM), in respect to DNA fragmentation and caspase-3 enzymatic activity. The apoptotic effect of citral depended on the α,β-unsaturated aldehyde group. © Georg Thieme Verlag KG Stuttgart.

Note:
Related Files :
apoptosis
Citrus limon
Cymbopogon citratus
human cell
plant extract
עוד תגיות
תוכן קשור
More details
DOI :
10.1055/s-2005-864146
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
29652
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:48
Scientific Publication
Citral is a new inducer of caspase-3 in tumor cell lines
71
Dudai, N., Hazeva Research and Development Center, Jacob Blaustein Institute for Desert Research, Ben Gurion University of the Negev, Beer Sheva, Israel
Weinstein, Y., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Krup, M., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Rabinski, T., Division of Aromatic Plants, ARO, Newe Yaar, Ramat Ishai, Israel
Ofir, R., Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
Citral is a new inducer of caspase-3 in tumor cell lines

Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investigated the anti-cancer potential of citral and its mode of action. Concentrations of 44.5 μM, comparable to the concentration of citral in a cup of tea prepared from 1 g of lemon grass, induced apoptosis in several hematopoietic cancer cell lines. Apoptosis was accompanied by DNA fragmentation and caspase-3 catalytic activity induction. Citral activity (22.25 μM) was compared to a reference compound like staurosporine (0.7 μM), in respect to DNA fragmentation and caspase-3 enzymatic activity. The apoptotic effect of citral depended on the α,β-unsaturated aldehyde group. © Georg Thieme Verlag KG Stuttgart.

Scientific Publication
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