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פותח על ידי קלירמאש פתרונות בע"מ -
Pituitary response to GnRH and ovariectomy in Booroola-Awassi and Awassi ewe lambs
Year:
1989
Authors :
בראב-טל, רות
;
.
גוטויין, אלישע
;
.
Volume :
87
Co-Authors:
Braw-Tal, R., Institute of Animal Science, A.R.O., Volcani Center, Bet Dagan 50250, Israel
Gootwine, E., Institute of Animal Science, A.R.O., Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
73
To page:
80
(
Total pages:
8
)
Abstract:
Booroola-Awassi ewe lambs were heterozygous (F+) for a major gene F, influencing their ovulation rate, while Awassi lambs were non-carriers (++). Basal plasma FSH concentration (mean ± s.e.m.) in Booroola-Awassi ewe lambs at 4 weeks of age was significantly higher than in Awassi lambs of the same age (5.06 ± 0.60 and 2.04 ± 0.32 ng/ml respectively; P < 0.001). After GnRH administration, FSH increased from 3.89 ± 1.10 to 10.58 ± 1.30 ng/ml in Booroola-Awassi (N = 6) and from 1.87 ± 0.29 to 4.64 ± 0.33 ng/ml in Awassi (N = 6) ewe lambs (P < 0.05). Ovariectomy caused an increase in plasma FSH in Booroola-Awassi (N = 4) and Awassi (N = 4) ewe lambs. At 1 week after ovariectomy plasma FSH increased from 5.96 ± 1.02 to 7.06 ± 1.05 ng/ml in F+ and from 1.67 ± 1.06 to 5.21 ± 0.66 ng/ml in ++ ewe lambs, suggesting a stronger negative feed-back effect exerted by the ovaries of Awassi lambs. At 15 weeks after ovariectomy FSH values were similar in Booroola-Awassi (18.28 ± 1.96 ng/ml) and Awassi (16.07 ± 0.70 ng/ml) lambs. Although the overall pattern of pituitary response to ovariectomy was similar in the F+ and ++ ewe lambs, Booroola-Awassi lambs had small ovaries (132.5 ± 24.9 mg) and follicular development did not proceed beyond the preantral stage in 3/4 animals, and Awassi lambs had large ovaries (600.0 ± 233.9 mg)(P < 0.05) with many preantral and antral follicles. The present results suggest that (1) the elevated plasma FSH concentration between 3 and 6 weeks of age in Booroola-Awassi compared to Awassi ewe lambs might be due to (a) greater responsiveness of the F+ pituitary to GnRH and (b) reduced ovarian suppression of FSH release and (2) the ovaries of Booroola-Awassi lambs, although lacking antral follicles, secrete a factor that controls FSH values. We suggest that differences between the two genotypes can be attributed to the F gene or to other minor genes that came from the Booroola-Merino sires used to create the Booroola-Awassi progeny.
Note:
Related Files :
Animal
animal experiment
Female
Follicle Stimulating Hormone
hypophysis
Male
ovariectomy
sheep
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
29734
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:49
Scientific Publication
Pituitary response to GnRH and ovariectomy in Booroola-Awassi and Awassi ewe lambs
87
Braw-Tal, R., Institute of Animal Science, A.R.O., Volcani Center, Bet Dagan 50250, Israel
Gootwine, E., Institute of Animal Science, A.R.O., Volcani Center, Bet Dagan 50250, Israel
Pituitary response to GnRH and ovariectomy in Booroola-Awassi and Awassi ewe lambs
Booroola-Awassi ewe lambs were heterozygous (F+) for a major gene F, influencing their ovulation rate, while Awassi lambs were non-carriers (++). Basal plasma FSH concentration (mean ± s.e.m.) in Booroola-Awassi ewe lambs at 4 weeks of age was significantly higher than in Awassi lambs of the same age (5.06 ± 0.60 and 2.04 ± 0.32 ng/ml respectively; P < 0.001). After GnRH administration, FSH increased from 3.89 ± 1.10 to 10.58 ± 1.30 ng/ml in Booroola-Awassi (N = 6) and from 1.87 ± 0.29 to 4.64 ± 0.33 ng/ml in Awassi (N = 6) ewe lambs (P < 0.05). Ovariectomy caused an increase in plasma FSH in Booroola-Awassi (N = 4) and Awassi (N = 4) ewe lambs. At 1 week after ovariectomy plasma FSH increased from 5.96 ± 1.02 to 7.06 ± 1.05 ng/ml in F+ and from 1.67 ± 1.06 to 5.21 ± 0.66 ng/ml in ++ ewe lambs, suggesting a stronger negative feed-back effect exerted by the ovaries of Awassi lambs. At 15 weeks after ovariectomy FSH values were similar in Booroola-Awassi (18.28 ± 1.96 ng/ml) and Awassi (16.07 ± 0.70 ng/ml) lambs. Although the overall pattern of pituitary response to ovariectomy was similar in the F+ and ++ ewe lambs, Booroola-Awassi lambs had small ovaries (132.5 ± 24.9 mg) and follicular development did not proceed beyond the preantral stage in 3/4 animals, and Awassi lambs had large ovaries (600.0 ± 233.9 mg)(P < 0.05) with many preantral and antral follicles. The present results suggest that (1) the elevated plasma FSH concentration between 3 and 6 weeks of age in Booroola-Awassi compared to Awassi ewe lambs might be due to (a) greater responsiveness of the F+ pituitary to GnRH and (b) reduced ovarian suppression of FSH release and (2) the ovaries of Booroola-Awassi lambs, although lacking antral follicles, secrete a factor that controls FSH values. We suggest that differences between the two genotypes can be attributed to the F gene or to other minor genes that came from the Booroola-Merino sires used to create the Booroola-Awassi progeny.
Scientific Publication
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