Maternal and embryonic transcripts of Drosophila proto-oncogenes are expressed in Schneider 2 culture cells but not in l(2)gl transformed neuroblasts

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Maternal and embryonic transcripts of Drosophila proto-oncogenes are expressed in Schneider 2 culture cells but not in l(2)gl transformed neuroblasts

Year: 

1989

Source of publication :

Cell Differentiation and Development

Authors :

שגב, אורית

.

Volume :

Co-Authors: 

Kimchie, Z., Department of Biology, Technion - Israel Institute of Technology, Haifa, Israel
Segev, O., Department of Biology, Technion - Israel Institute of Technology, Haifa, Israel
Lev, Z., Department of Biology, Technion - Israel Institute of Technology, Haifa, Israel

From page: 

79

To page: 

86

(

Total pages: 

8

)

Link :

Maternal and embryonic transcripts of Drosophila proto-oncogenes are expressed in Schneider 2 culture cells but not in l(2)gl transformed neuroblasts

Abstract: 

The transcription patterns of Drosophila melanogaster src, abl and two ras homologs were analyzed in normal Drosophila tissue, in neuroblasts derived from tumorous larval brain of the mutant lethal(2)giant larvae [l(2)gl] and in Schneider 2 tissue culture cells. Our results show that, in addition to constitutive transcripts, the src, abl, ras1 and ras3 genes express a set of maternal/embryonic-specific transcripts. By using these transcripts as differentiation markers we show that, in spite of their embryonic-like, undifferentiated phenotype, the l(2)gl transformed neuroblasts are authentic larval cells. Using the same criterion the Schneider 2 tissue culture cells show the characteristics of embryonic cells. © 1989.