נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart
Year:
1983
Source of publication :
European Journal of Pharmacology
Authors :
עזרא, דוד
;
.
Volume :
89
Co-Authors:
Boyd, L.M., Division of Cardiology, Department of Medicine, Neurobiology Research Unit, Bethesda, MD 20814, United States, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Neurobiology Research Unit, Bethesda, MD 20814, United States
Ezra, D., Division of Cardiology, Department of Medicine, Neurobiology Research Unit, Bethesda, MD 20814, United States, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Neurobiology Research Unit, Bethesda, MD 20814, United States
Feuerstein, G., Division of Cardiology, Department of Medicine, Neurobiology Research Unit, Bethesda, MD 20814, United States, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Neurobiology Research Unit, Bethesda, MD 20814, United States
Goldstein, R.E., Division of Cardiology, Department of Medicine, Neurobiology Research Unit, Bethesda, MD 20814, United States, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Neurobiology Research Unit, Bethesda, MD 20814, United States
Facilitators :
From page:
307
To page:
311
(
Total pages:
5
)
Abstract:
Intracoronary leukotriene D4, 0.1-3.0 μg (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 μg leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations is coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction. © 1983.
Note:
Related Files :
Animal
animal experiment
Female
Male
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/0014-2999(83)90512-5
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
29950
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:50
Scientific Publication
Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart
89
Boyd, L.M., Division of Cardiology, Department of Medicine, Neurobiology Research Unit, Bethesda, MD 20814, United States, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Neurobiology Research Unit, Bethesda, MD 20814, United States
Ezra, D., Division of Cardiology, Department of Medicine, Neurobiology Research Unit, Bethesda, MD 20814, United States, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Neurobiology Research Unit, Bethesda, MD 20814, United States
Feuerstein, G., Division of Cardiology, Department of Medicine, Neurobiology Research Unit, Bethesda, MD 20814, United States, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Neurobiology Research Unit, Bethesda, MD 20814, United States
Goldstein, R.E., Division of Cardiology, Department of Medicine, Neurobiology Research Unit, Bethesda, MD 20814, United States, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Neurobiology Research Unit, Bethesda, MD 20814, United States
Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart
Intracoronary leukotriene D4, 0.1-3.0 μg (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 μg leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations is coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction. © 1983.
Scientific Publication
You may also be interested in