Selective inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions

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פותח על ידי קלירמאש פתרונות בע"מ -

Selective inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions

Year: 

1978

Source of publication :

Virology

Authors :

צ'חנובסקי, נור

.

Volume :

Co-Authors: 

Fridlender, B., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Chejanovsky, N., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Becker, Y., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel

From page: 

551

To page: 

554

(

Total pages: 

4

)

Link :

Selective inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions

Abstract: 

The DNA polymerase of herpes simplex virus (HSV) was isolated from nuclei of infected BSC-1 cells by centrifugation in sucrose gradients and by chromatography on double-stranded DNA cellulose columns. The viral enzyme was almost completely inhibited in vitro by 0.1 mM zinc acetate. The a and β cellular DNA polymerases were resistant to 0.3 mM zinc acetate when tested under in vitro conditions. Inhibition of HSV replication can be explained by the selective inhibitory effect of zinc ions on the viral DNA polymerase. © 1978.