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פותח על ידי קלירמאש פתרונות בע"מ -
The biocide chlorine dioxide stimulates biofilm formation in Bacillus subtilis by activation of the histidine kinase KinC
Year:
2010
Source of publication :
Journal of Bacteriology
Authors :
שמש, משה
;
.
Volume :
192
Co-Authors:
Shemesh, M., Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, United States
Kolter, R., Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, United States
Losick, R., Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, United States
Facilitators :
From page:
6352
To page:
6356
(
Total pages:
5
)
Abstract:
Bacillus subtilis forms biofilms in response to signals that remain poorly defined. We report that biofilm formation is stimulated by sublethal doses of chlorine dioxide (ClO2), an extremely effective and fast-acting biocide. ClO2 accelerated biofilm formation in B. subtilis as well as in other bacteria, suggesting that biofilm formation is a widely conserved response to sublethal doses of the agent. Biofilm formation depends on the synthesis of an extracellular matrix that holds the constituent cells together. We show that the transcription of the major operons responsible for the matrix production in B. subtilis, epsA-epsO and yqxM-sipW-tasA, was enhanced by ClO2, in a manner that depended on the membrane-bound kinase KinC. Activation of KinC appeared to be due to the ability of ClO2 to collapse the membrane potential. Importantly, strains unable to make a matrix were hypersensitive to ClO2, indicating that biofilm formation is a defensive response that helps protect cells from the toxic effects of the biocide. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Note:
Related Files :
bacterial membrane
bacterial strain
Biocide
membrane potential
Oxides
protein histidine kinase
Protein Kinases
unclassified drug
עוד תגיות
תוכן קשור
More details
DOI :
10.1128/JB.01025-10
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
30055
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:51
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Scientific Publication
The biocide chlorine dioxide stimulates biofilm formation in Bacillus subtilis by activation of the histidine kinase KinC
192
Shemesh, M., Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, United States
Kolter, R., Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, United States
Losick, R., Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, United States
The biocide chlorine dioxide stimulates biofilm formation in Bacillus subtilis by activation of the histidine kinase KinC
Bacillus subtilis forms biofilms in response to signals that remain poorly defined. We report that biofilm formation is stimulated by sublethal doses of chlorine dioxide (ClO2), an extremely effective and fast-acting biocide. ClO2 accelerated biofilm formation in B. subtilis as well as in other bacteria, suggesting that biofilm formation is a widely conserved response to sublethal doses of the agent. Biofilm formation depends on the synthesis of an extracellular matrix that holds the constituent cells together. We show that the transcription of the major operons responsible for the matrix production in B. subtilis, epsA-epsO and yqxM-sipW-tasA, was enhanced by ClO2, in a manner that depended on the membrane-bound kinase KinC. Activation of KinC appeared to be due to the ability of ClO2 to collapse the membrane potential. Importantly, strains unable to make a matrix were hypersensitive to ClO2, indicating that biofilm formation is a defensive response that helps protect cells from the toxic effects of the biocide. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Scientific Publication
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