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פותח על ידי קלירמאש פתרונות בע"מ -
Protein deprivation attenuates Hsp expression in fat tissue
Year:
2012
Source of publication :
Cell Stress and Chaperones
Authors :
אורלוב, אלה
;
.
איתם, הראל
;
.
ברוש, אריה
;
.
שבתאי, אריאל
;
.
Volume :
17
Co-Authors:
Eitam, H., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel, Department of Evolutionary and Environmental Biology, Faculty of Science and Science Education, University of Haifa, 31905 Haifa, Israel
Agmon, R., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Asher, A., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Brosh, A., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Orlov, A., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Izhaki, I., Department of Evolutionary and Environmental Biology, Faculty of Science and Science Education, University of Haifa, 31905 Haifa, Israel
Shabtay, A., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Facilitators :
From page:
339
To page:
347
(
Total pages:
9
)
Abstract:
For ruminants, dietary protein is the first limiting component to the utilization of low-quality forage. Throughout gestation, low-protein intake may result in prenatal programming that causes various metabolic disturbances and physiological modulations to dams and their developing embryos. We studied the effect of long-term low-protein diet (LPD) on physiological, biochemical, and molecular parameters of the energy status in gestating beef cows. LPD resulted in significant reductions in feed intake and heart rate and promoted a negative retained energy status already after 3 weeks. Elevated levels of plasma creatinine and non-esterified fatty acids indicate endogenous degradation of fat and protein as a response to the demands in energy and nitrogen. Increasing levels of â- hydroxybutyrate confirmed the negative energy status obtained by the physiological measurements. At the molecular level, subcutaneous fat, Hsp90, Hsp70, and proteasome subunits decreased significantly after 3 months on LPD, in parallel with an increase of adipocyte fatty acidbinding protein. These results may indicate a decrease in turn-over of proteins, at the cost of induced lipolysis, and suggest that the response to protein deprivation, when examined in an energy-storing tissue, includes downregulation of the constitutive heat shock proteins involved in the protein degradation pathway of energy production and upregulation of tissue-specific genes such as those involved in energy production from fat degradation. © 2011 Cell Stress Society International.
Note:
Related Files :
3 hydroxybutyric acid
adipose tissue
animal experiment
Animals
cattle
Female
heart rate
Ruminants
עוד תגיות
תוכן קשור
More details
DOI :
10.1007/s12192-011-0308-0
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
30238
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:53
Scientific Publication
Protein deprivation attenuates Hsp expression in fat tissue
17
Eitam, H., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel, Department of Evolutionary and Environmental Biology, Faculty of Science and Science Education, University of Haifa, 31905 Haifa, Israel
Agmon, R., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Asher, A., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Brosh, A., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Orlov, A., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Izhaki, I., Department of Evolutionary and Environmental Biology, Faculty of Science and Science Education, University of Haifa, 31905 Haifa, Israel
Shabtay, A., Institute of Animal Science, Department of Ruminant Science, Newe ya'Ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel
Protein deprivation attenuates Hsp expression in fat tissue
For ruminants, dietary protein is the first limiting component to the utilization of low-quality forage. Throughout gestation, low-protein intake may result in prenatal programming that causes various metabolic disturbances and physiological modulations to dams and their developing embryos. We studied the effect of long-term low-protein diet (LPD) on physiological, biochemical, and molecular parameters of the energy status in gestating beef cows. LPD resulted in significant reductions in feed intake and heart rate and promoted a negative retained energy status already after 3 weeks. Elevated levels of plasma creatinine and non-esterified fatty acids indicate endogenous degradation of fat and protein as a response to the demands in energy and nitrogen. Increasing levels of â- hydroxybutyrate confirmed the negative energy status obtained by the physiological measurements. At the molecular level, subcutaneous fat, Hsp90, Hsp70, and proteasome subunits decreased significantly after 3 months on LPD, in parallel with an increase of adipocyte fatty acidbinding protein. These results may indicate a decrease in turn-over of proteins, at the cost of induced lipolysis, and suggest that the response to protein deprivation, when examined in an energy-storing tissue, includes downregulation of the constitutive heat shock proteins involved in the protein degradation pathway of energy production and upregulation of tissue-specific genes such as those involved in energy production from fat degradation. © 2011 Cell Stress Society International.
Scientific Publication
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