אסיף מאגר המחקר החקלאי

Pharmaceuticals

Year:

2009

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Co-Authors:

Piersma, A.H., Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, Netherlands
Luijten, M., Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, Netherlands
Popov, V., Wessex Institute of Technology, Ashurst Lodge, Ashurst, Southampton, SO40 7AA, United Kingdom
Tomenko, V., Wessex Institute of Technology, Ashurst Lodge, Ashurst, Southampton, SO40 7AA, United Kingdom
Altstein, M., Institute of Plant Protection, The Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel
Kagampang, F., Analyst Research Laboratories Ltd., Rabin Park, 12 Hanada St, Rehovot 76703, Israel
Schlesinger, H., Analyst Research Laboratories Ltd., Rabin Park, 12 Hanada St, Rehovot 76703, Israel

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Abstract:

An inventory is presented of pharmaceuticals with a potential to affect human fecundity via exposure through the human food chain. Pharmaceuticals are reviewed in particular with respect to their mechanism of action, especially in view of endocrine disruption, their use pattern and their detection and persistence in the environment as important indicators of possible human exposure via the food chain. Sections on mechanisms of toxicity to fertility and on nutritional exposure pathways are followed by an extensive review of a series of relevant classes of pharmaceuticals. Finally, risk assessment approaches are reviewed. This work has been conducted as the first phase in the EU-FP6 project Food &Fecundity (F&) as part of the identification of pharmaceutical compounds of interest for further analysis in food matrices. © 2009 Woodhead Publishing Limited All rights reserved.

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