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פותח על ידי קלירמאש פתרונות בע"מ -
THE EFFECT OF SUBSTITUENTS ON PHTHALOCYANINE PHOTOCYTOTOXICITY
Year:
1987
Source of publication :
Photochemistry and Photobiology
Authors :
רוזנטל, יונל
;
.
Volume :
46
Co-Authors:
Rosenthal, I., Department of Food Science, AR.O, The Volcani Center, PO. Box 6, Bet-Dagan, Israel
Ben‐Hur, E., Department of Radiobiology, Nuclear Research Centre-Negev, P.O. Box 9001, Beer-Sheva, Israel
Greenberg, S., Department of Chemistry, York University, North York, Ontario, M3J 1P3, Canada
Concepcion‐Lam, A., Department of Chemistry, York University, North York, Ontario, M3J 1P3, Canada
Drew, D.M., Department of Chemistry, York University, North York, Ontario, M3J 1P3, Canada
Leznoff, C.C., Department of Chemistry, York University, North York, Ontario, M3J 1P3, Canada
Facilitators :
From page:
959
To page:
963
(
Total pages:
5
)
Abstract:
Phthalocyanine (Pc) dyes are a class of photosensitizers that are being considered for use in the photodynamic therapy of cancer. A final choice for the most useful drug demands phototoxicity screening of various structurally related Pc dyes, such as those with different substituents at the peripheral benzene rings. Using the colony forming ability of Chinese hamster cells as an endpoint, the photobiological activity for ZnPc was found to be the highest for the unsubstituted compound, followed in decreasing order by the 2,9,16,23‐tetrahydroxy‐, 2,9,16,23‐tetrasulfonated‐, and 2,9,16,23‐tetraneopentoxy‐Pc derivatives. This effect could be correlated with the uptake rate of the respective Pc derivatives by the cells, but it is unrelated to the apparent lipophilicity of these compounds, or, alternatively, to their ability to photogenerate singlet oxygen. The first synthesis of a metal‐free tetrahydroxy Pc is described. Copyright © 1987, Wiley Blackwell. All rights reserved
Note:
Related Files :
Animal
cell line
drug effect
light
phthalocyanine
Radiation Sensitizing Agents
radiosensitizing agent
עוד תגיות
תוכן קשור
More details
DOI :
10.1111/j.1751-1097.1987.tb04877.x
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
30698
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:56
Scientific Publication
THE EFFECT OF SUBSTITUENTS ON PHTHALOCYANINE PHOTOCYTOTOXICITY
46
Rosenthal, I., Department of Food Science, AR.O, The Volcani Center, PO. Box 6, Bet-Dagan, Israel
Ben‐Hur, E., Department of Radiobiology, Nuclear Research Centre-Negev, P.O. Box 9001, Beer-Sheva, Israel
Greenberg, S., Department of Chemistry, York University, North York, Ontario, M3J 1P3, Canada
Concepcion‐Lam, A., Department of Chemistry, York University, North York, Ontario, M3J 1P3, Canada
Drew, D.M., Department of Chemistry, York University, North York, Ontario, M3J 1P3, Canada
Leznoff, C.C., Department of Chemistry, York University, North York, Ontario, M3J 1P3, Canada
THE EFFECT OF SUBSTITUENTS ON PHTHALOCYANINE PHOTOCYTOTOXICITY
Phthalocyanine (Pc) dyes are a class of photosensitizers that are being considered for use in the photodynamic therapy of cancer. A final choice for the most useful drug demands phototoxicity screening of various structurally related Pc dyes, such as those with different substituents at the peripheral benzene rings. Using the colony forming ability of Chinese hamster cells as an endpoint, the photobiological activity for ZnPc was found to be the highest for the unsubstituted compound, followed in decreasing order by the 2,9,16,23‐tetrahydroxy‐, 2,9,16,23‐tetrasulfonated‐, and 2,9,16,23‐tetraneopentoxy‐Pc derivatives. This effect could be correlated with the uptake rate of the respective Pc derivatives by the cells, but it is unrelated to the apparent lipophilicity of these compounds, or, alternatively, to their ability to photogenerate singlet oxygen. The first synthesis of a metal‐free tetrahydroxy Pc is described. Copyright © 1987, Wiley Blackwell. All rights reserved
Scientific Publication
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