אסיף מאגר המחקר החקלאי

Significance of fumigant residues in animal feed [ISOTOPE TRACES STUDIES OF CHEMICAL RESIDUES IN FOOD AND THE AGRICULTURAL ENVIRONMENT: PROCEEDINGS]

Year:

1974

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Co-Authors:

Alumot, E., Div. Anim. Nutrit., Volcani Cent., Agric. Res. Organ., Bet Dagan, Israel
Nachtomi, E., Div. Anim. Nutrit., Volcani Cent., Agric. Res. Organ., Bet Dagan, Israel
Bielorai, R., Div. Anim. Nutrit., Volcani Cent., Agric. Res. Organ., Bet Dagan, Israel
Harduf, Z., Div. Anim. Nutrit., Volcani Cent., Agric. Res. Organ., Bet Dagan, Israel

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Abstract:

The chronic effects of ethylene dibromide (EDB) on chicken and rats were investigated in order to find out to what extent biochemical reactions involved in chronic poisoning by that compound are analogous to those in acute poisoning. The mechanism of acute EDB poisoning was also compared with that of acute carbon tetrachloride (CTC) poisoning. The study concentrated on the following main processes: occurrence of fatty livers, lipid oxidation in microsomal membranes and reactions with SH groups. Also methods were developed for controlling fumigant losses from feed and for accurate intake estimates in long term feeding trials. It was concluded that EDB and CTC have different modes of acute action on a given species; these findings were supported by chronic intake studies. The formation of fatty livers appeared to be the most important symptom both in chronic and acute CTC poisoning, whereas EDB and ethylene dichloride (EDC) did not affect liver fat. Also chronic EDB poisoning did not change the levels of liver SH groups as is observed in acute poisoning.

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