Co-Authors:
Budowski, P., Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel
Bartov, I., Division of Poultry Science, Agricultural Research Organization, The Volcani Center, Renovot, Israel
Dror, Y., Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel
Frankel, E.N., Northern Regional Research Center, Agricultural Research, Science and Education Administration, U.S. Department of Agriculture, Peoria, 61604, Illinois, United States
Abstract:
Safflower oil and its distilled methyl esters were thermally oxidized and fed to young chicks in a vitamin E deficient diet. At a dietary level of 10%, the oxidized lipids caused more severe nutritional encephalopathy (NE) than the unoxidized methyl esters, indicating that factors other than dietary linoleic acid and vitamin E affect the development of NE. A polar lipid extract from oxidized methyl esters accelerated the induction of NE, as did the synthetic methyl esters of keto-octadecenoic and keto-octadecadienoic acids. Dicumarol exerted a protective action against NE. The possibility is discussed that conjugated keto-polyenoic fatty acids, provided by oxidized oils or formed endogenously in vitamin E deficiency, may play a role in causing NE. © 1979 American Oil Chemists' Society.