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פותח על ידי קלירמאש פתרונות בע"מ -
The rate of cell growth is governed by cell cycle stage
Year:
2009
Source of publication :
Genes and Development
Authors :
בן-ארי, גיורא
;
.
Volume :
23
Co-Authors:
Goranov, A.I., David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, MA 02139, United States
Cook, M., Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
Ricicova, M., Centre for High-Throughput Biology, Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Ben-Ari, G., Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
Gonzalez, C., David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, MA 02139, United States
Hansen, C., Centre for High-Throughput Biology, Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Tyers, M., Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada, Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
Amon, A., David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, MA 02139, United States
Facilitators :
From page:
1408
To page:
1422
(
Total pages:
15
)
Abstract:
Cell growth is an essential requirement for cell cycle progression. While it is often held that growth is independent of cell cycle position, this relationship has not been closely scrutinized. Here we show that in budding yeast, the ability of cells to grow changes during the cell cycle. We find that cell growth is faster in cells arrested in anaphase and G1 than in other cell cycle stages. We demonstrate that the establishment of a polarized actin cytoskeleton-either as a consequence of normal cell division or through activation of the mating pheromone response-potently attenuates protein synthesis and growth. We furthermore show by population and single-cell analysis that growth varies during an unperturbed cell cycle, slowing at the time of polarized growth. Our study uncovers a fundamental relationship whereby cell cycle position regulates growth. © 2009 by Cold Spring Harbor Laboratory Press.
Note:
Related Files :
animal cell
Cell Division
cell enlargement
drug effect
Genetics
Growth, Development and Aging
metabolism
mutation
pheromones
עוד תגיות
תוכן קשור
More details
DOI :
10.1101/gad.1777309
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
31182
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:00
You may also be interested in
Scientific Publication
The rate of cell growth is governed by cell cycle stage
23
Goranov, A.I., David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, MA 02139, United States
Cook, M., Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
Ricicova, M., Centre for High-Throughput Biology, Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Ben-Ari, G., Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
Gonzalez, C., David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, MA 02139, United States
Hansen, C., Centre for High-Throughput Biology, Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Tyers, M., Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada, Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
Amon, A., David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, MA 02139, United States
The rate of cell growth is governed by cell cycle stage
Cell growth is an essential requirement for cell cycle progression. While it is often held that growth is independent of cell cycle position, this relationship has not been closely scrutinized. Here we show that in budding yeast, the ability of cells to grow changes during the cell cycle. We find that cell growth is faster in cells arrested in anaphase and G1 than in other cell cycle stages. We demonstrate that the establishment of a polarized actin cytoskeleton-either as a consequence of normal cell division or through activation of the mating pheromone response-potently attenuates protein synthesis and growth. We furthermore show by population and single-cell analysis that growth varies during an unperturbed cell cycle, slowing at the time of polarized growth. Our study uncovers a fundamental relationship whereby cell cycle position regulates growth. © 2009 by Cold Spring Harbor Laboratory Press.
Scientific Publication
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