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פותח על ידי קלירמאש פתרונות בע"מ -
The effect of the long-term feeding of raw soy flour on the pancreas of the mouse and hamster.
Year:
1986
Authors :
חסדאי, אהרון
;
.
Volume :
199
Co-Authors:
Liener, I.E.
Hasdai, A.
Facilitators :
From page:
189
To page:
197
(
Total pages:
9
)
Abstract:
The effects of the long-term feeding of mice and hamsters with raw (RSF) or heated (HSF) soy flours were investigated both in the presence and absence of chemical carcinogens. Mice which had been fed RSF for 18 months had enlarged pancreas but only a relatively low incidence of atypical acinar cell nodules (AACN). Mice on either RSF or HSF were also relatively resistant to the carcinogenic effects of azaserine which is known to produce a high incidence of AACN in rats. Hamsters which had been fed RSF for 15 months did not exhibit pancreatic enlargement and had a very low incidence of pancreatic tumors. Although the incidence of tumors in hamsters which had been injected with N-nitrosobis (2-oxopropyl)amine and maintained on HSF was very high (88%), those on RSF had a tumor incidence of less than 10%. Thus, there appears to be a marked difference in the response of the pancreas in different species of animals to the long-term effects of feeding RSF. This should be taken into consideration in evaluating the potential carcinogenicity of the trypsin inhibitors.
Note:
Related Files :
Animal
azaserine
drug effect
Hamsters
Male
mice
mouse
Pancreas
Pathology
soybean
species difference
Species Specificity
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
31220
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:00
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Scientific Publication
The effect of the long-term feeding of raw soy flour on the pancreas of the mouse and hamster.
199
Liener, I.E.
Hasdai, A.
The effect of the long-term feeding of raw soy flour on the pancreas of the mouse and hamster.
The effects of the long-term feeding of mice and hamsters with raw (RSF) or heated (HSF) soy flours were investigated both in the presence and absence of chemical carcinogens. Mice which had been fed RSF for 18 months had enlarged pancreas but only a relatively low incidence of atypical acinar cell nodules (AACN). Mice on either RSF or HSF were also relatively resistant to the carcinogenic effects of azaserine which is known to produce a high incidence of AACN in rats. Hamsters which had been fed RSF for 15 months did not exhibit pancreatic enlargement and had a very low incidence of pancreatic tumors. Although the incidence of tumors in hamsters which had been injected with N-nitrosobis (2-oxopropyl)amine and maintained on HSF was very high (88%), those on RSF had a tumor incidence of less than 10%. Thus, there appears to be a marked difference in the response of the pancreas in different species of animals to the long-term effects of feeding RSF. This should be taken into consideration in evaluating the potential carcinogenicity of the trypsin inhibitors.
Scientific Publication
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