חיפוש מתקדם
Cavallaro, S., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States, Inst. Biomimagini Fisiopatol. S., Catania, Italy
Meiri, N., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States
Yi, C.-L., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States
Musco, S., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States
Ma, W., Biotech. Res. and Applic. Division, Sci. Applic. Intl. Corporation, Rockville, MD 20850, United States
Goldberg, J., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States
Alkon, D.L., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States, Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, 36 Convent Drive, Bethesda, MD 20892-4124, United States
Although long-term memory is thought to require a cellular program of gene expression and increased protein synthesis, the identity of proteins critical for associative memory is largely unknown. We used RNA fingerprinting to identify candidate memory-related genes (MRGs), which were upregulated in the hippocampus of water maze-trained rats, a brain area that is critically involved in spatial learning. Two of the original 10 candidate genes implicated by RNA fingerprinting, the rat homolog of the ryanodine receptor type-2 and glutamate dehydrogenase (EC 1.4.1.3), were further investigated by Northern blot analysis, reverse transcription-PCR, and in situ hybridization and confirmed as MRGs with distinct temporal and regional expression. Successive RNA screening as illustrated here may help to reveal a spectrum of MRGs as they appear in distinct domains of memory storage.
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תנאי שימוש
Late memory-related genes in the hippocampus revealed by RNA fingerprinting
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Cavallaro, S., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States, Inst. Biomimagini Fisiopatol. S., Catania, Italy
Meiri, N., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States
Yi, C.-L., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States
Musco, S., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States
Ma, W., Biotech. Res. and Applic. Division, Sci. Applic. Intl. Corporation, Rockville, MD 20850, United States
Goldberg, J., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States
Alkon, D.L., Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, Bethesda, MD 20892, United States, Laboratory of Adaptive Systems, Natl. Inst. Neurol. Disord. Stroke, National Institutes of Health, 36 Convent Drive, Bethesda, MD 20892-4124, United States
Late memory-related genes in the hippocampus revealed by RNA fingerprinting
Although long-term memory is thought to require a cellular program of gene expression and increased protein synthesis, the identity of proteins critical for associative memory is largely unknown. We used RNA fingerprinting to identify candidate memory-related genes (MRGs), which were upregulated in the hippocampus of water maze-trained rats, a brain area that is critically involved in spatial learning. Two of the original 10 candidate genes implicated by RNA fingerprinting, the rat homolog of the ryanodine receptor type-2 and glutamate dehydrogenase (EC 1.4.1.3), were further investigated by Northern blot analysis, reverse transcription-PCR, and in situ hybridization and confirmed as MRGs with distinct temporal and regional expression. Successive RNA screening as illustrated here may help to reveal a spectrum of MRGs as they appear in distinct domains of memory storage.
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