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פותח על ידי קלירמאש פתרונות בע"מ -
The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13
Year:
1997
Source of publication :
Human Genetics
Authors :
סרוסי, אייל
;
.
Volume :
100
Co-Authors:
Kedra, D., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Seroussi, E., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Fransson, I., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Trifunovic, J., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Clark, M., MRC-HGMP Resource Centre, Hinxton, Cambridge CB10 2SB, United Kingdom
Lagercrantz, J., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Blennow, E., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Mehlin, H., Department of Cell Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden
Dumanski, J., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Facilitators :
From page:
611
To page:
619
(
Total pages:
9
)
Abstract:
Multiple endocrine neoplasia type 1 (MEN 1)is tightly linked to the muscle-type glycogen phosphorylase (PYGM) gene in 11q13. This region of the human genome contains additional disease-related loci implicated in the development of insulin-dependent diabetes mellitus, familial paraganglioma type 2, spinocerebellar ataxia type 5, Bardet-Biedl syndrome and translocation t(11;17) described in B-cell non-Hodgkin's lymphoma. We approached cloning of candidate disease genes from 11q13 by large-scale genomic sequencing. We obtained > 106 kb of sequence around the PYGM gene and established a transcriptional map that includes: (i) two genes previously localized to 11q13, PYGM and a zinc-finger protein (ZFM1) gene; (ii) the germinal center kinase (GCK, human B-lymphocyte serine/threonine protein kinase) gene; (iii) a novel human CDC25-like (HCDC25L) gene; (iv) a dystrophia myotonica protein kinase-like (DMPKL) gene; and (v) a novel ubiquitously expressed gene of unknown function (germinal center kinase-neighboring gene, GCKNG).
Note:
Related Files :
chromosome mapping
gene mapping
Genes
Nuclear Proteins
ras-GRF1
Sequence Homology, Amino Acid
עוד תגיות
תוכן קשור
More details
DOI :
10.1007/s004390050562
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
31388
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:02
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Scientific Publication
The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13
100
Kedra, D., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Seroussi, E., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Fransson, I., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Trifunovic, J., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Clark, M., MRC-HGMP Resource Centre, Hinxton, Cambridge CB10 2SB, United Kingdom
Lagercrantz, J., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Blennow, E., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
Mehlin, H., Department of Cell Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden
Dumanski, J., Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden
The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13
Multiple endocrine neoplasia type 1 (MEN 1)is tightly linked to the muscle-type glycogen phosphorylase (PYGM) gene in 11q13. This region of the human genome contains additional disease-related loci implicated in the development of insulin-dependent diabetes mellitus, familial paraganglioma type 2, spinocerebellar ataxia type 5, Bardet-Biedl syndrome and translocation t(11;17) described in B-cell non-Hodgkin's lymphoma. We approached cloning of candidate disease genes from 11q13 by large-scale genomic sequencing. We obtained > 106 kb of sequence around the PYGM gene and established a transcriptional map that includes: (i) two genes previously localized to 11q13, PYGM and a zinc-finger protein (ZFM1) gene; (ii) the germinal center kinase (GCK, human B-lymphocyte serine/threonine protein kinase) gene; (iii) a novel human CDC25-like (HCDC25L) gene; (iv) a dystrophia myotonica protein kinase-like (DMPKL) gene; and (v) a novel ubiquitously expressed gene of unknown function (germinal center kinase-neighboring gene, GCKNG).
Scientific Publication
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