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Milk glucose-6-phosphate dehydrogenase activity and glucose-6-phosphate are associated with oxidative stress and serve as indicators of energy balance in dairy cows
Year:
2016
Source of publication :
RSC Advances
Authors :
זכות, מאיה
;
.
סילניקוב, ניסים
;
.
פורטניק, יורי
;
.
קרא, גיתית
;
.
שפירו, פירה
;
.
Volume :
6
Co-Authors:
Zachut, M., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Kra, G., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Portnik, Y., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Shapiro, F., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Silanikove, N., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Facilitators :
From page:
65412
To page:
65417
(
Total pages:
6
)
Abstract:

Early lactation in high-producing dairy cows is associated with negative energy balance (EB) and with massive lipolysis to support the energy demands for milk production. The large influx of free fatty acids and glycerol increases oxidative stress in the mammary gland. Milk concentrations of glucose and glucose-6-phosphate (G6P), activity of glucose-6-phosphate dehydrogenase (G6PDH), level of the oxidative stress marker malondialdehyde (MDA), total antioxidant capacity of milk, calculated EB and various parameters reflecting EB (plasma concentrations of nonesterified fatty acids and body condition score), and glucose metabolism (plasma insulin concentration) were measured in 12 high-yielding dairy cows in early lactation (3-57 days in lactation), once a week for 4 weeks. Weekly averages of milk glucose concentration increased from 81 to 184 μM, and of milk G6P decreased from 223 to 81 μM. The activity of milk G6PDH decreased from 902.8 to 256.4 mU ml-1, so that the G6P/glucose ratio in milk decreased from 3.5 to 0.5. A significant correlation between milk G6PDH activity and milk G6P concentration, and an inverse relationship between milk MDA concentration and days in lactation suggest that G6P is shunted to the pentose phosphate pathway in the mammary gland in early lactation, as part of a homeostatic adaptation to counterbalance the excess oxidative stress during early lactation in dairy cows. Milk G6P concentration and G6P/glucose ratio may serve as objective, accurate and noninvasive indicators of EB in dairy cows and potentially in other mammals subjected to negative EB and oxidative stress. © 2016 The Royal Society of Chemistry.

Note:
Related Files :
Dairies
fatty acids
Glucose-6-phosphate dehydrogenase
Glucose concentration
Nonesterified fatty acids
עוד תגיות
תוכן קשור
More details
DOI :
10.1039/c6ra11924g
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
31477
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:02
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Scientific Publication
Milk glucose-6-phosphate dehydrogenase activity and glucose-6-phosphate are associated with oxidative stress and serve as indicators of energy balance in dairy cows
6
Zachut, M., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Kra, G., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Portnik, Y., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Shapiro, F., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Silanikove, N., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Milk glucose-6-phosphate dehydrogenase activity and glucose-6-phosphate are associated with oxidative stress and serve as indicators of energy balance in dairy cows

Early lactation in high-producing dairy cows is associated with negative energy balance (EB) and with massive lipolysis to support the energy demands for milk production. The large influx of free fatty acids and glycerol increases oxidative stress in the mammary gland. Milk concentrations of glucose and glucose-6-phosphate (G6P), activity of glucose-6-phosphate dehydrogenase (G6PDH), level of the oxidative stress marker malondialdehyde (MDA), total antioxidant capacity of milk, calculated EB and various parameters reflecting EB (plasma concentrations of nonesterified fatty acids and body condition score), and glucose metabolism (plasma insulin concentration) were measured in 12 high-yielding dairy cows in early lactation (3-57 days in lactation), once a week for 4 weeks. Weekly averages of milk glucose concentration increased from 81 to 184 μM, and of milk G6P decreased from 223 to 81 μM. The activity of milk G6PDH decreased from 902.8 to 256.4 mU ml-1, so that the G6P/glucose ratio in milk decreased from 3.5 to 0.5. A significant correlation between milk G6PDH activity and milk G6P concentration, and an inverse relationship between milk MDA concentration and days in lactation suggest that G6P is shunted to the pentose phosphate pathway in the mammary gland in early lactation, as part of a homeostatic adaptation to counterbalance the excess oxidative stress during early lactation in dairy cows. Milk G6P concentration and G6P/glucose ratio may serve as objective, accurate and noninvasive indicators of EB in dairy cows and potentially in other mammals subjected to negative EB and oxidative stress. © 2016 The Royal Society of Chemistry.

Scientific Publication
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