Both cholera toxin-induced adenylate cyclase activation and cholera toxin biological activity are inhibited by antibodies against related synthetic peptides

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פותח על ידי קלירמאש פתרונות בע"מ -

Both cholera toxin-induced adenylate cyclase activation and cholera toxin biological activity are inhibited by antibodies against related synthetic peptides

Year: 

1984

Source of publication :

Proceedings of the National Academy of Sciences of the United States of America

Authors :

הורויץ, שמואל (בעלי חיים)

;

פינס, מרק

.

Volume :

Co-Authors: 

Jacob, C.O., Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Sela, M., Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Pines, M., Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Hurwitz, S.
Arnon, R.

From page: 

7893

To page: 

7896

(

Total pages: 

4

)

Link :

Both cholera toxin-induced adenylate cyclase activation and cholera toxin biological activity are inhibited by antibodies against related synthetic peptides

Abstract: 

The immune response against six synthetic peptides corresponding to various segments of the B subunit of cholera toxin was evaluated. Conjugates in which the peptides were covalently linked to tetanus toxoid served for immunization of rabbits. As previously reported, four of these conjugates elicited antibodies cross-reactive with intact cholera toxin. We report here that antisera against two of these synthetic peptides inhibit the entire spectrum of activities of the intact cholera toxin. This is maintained both on the biochemical level (adenylate cyclase induction) and on the biological effect (intestinal fluid secretion). These results indicate that these peptides may serve as suitable candidates for preparation of a synthetic anticholera vaccine.