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Food and Cosmetics Toxicology
Alumot, E., Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Meidler, M., Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Holstein, P., Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Herzberg, M., Ichilov Hospital, Tel Aviv, Israel
Leghorn chickens of both sexes were fed mash fumigated with ethylene dichloride (1,2-dichloroethane) for 2 yr. Growth, performance of layers, fertility, reproduction and biochemical tests served as criteria for establishing the no-effect levels. Ethylene dichloride did not affect the growth, semen characteristics or fertility of the chickens, and the results of serum analyses on treated chickens did not differ from those on controls. Both fumigant levels, 250 and 500 ppm in the mash, caused a moderate but persistent decrease in egg weight from month 4 of the laying period. Egg production was affected only by the higher level of fumigant. A tolerance of 100 ppm and an acceptable daily intake of 5 mg/kg body weight seem to be justified for laying hens. For growing chicks and cocks the tolerance and acceptable daily intake are the same as those previously determined for rats, namely 250 ppm and 25 mg/kg, respectively. © 1976 Pergamon Press.
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Tolerance and acceptable daily intake of ethylene dichloride in the chicken diet
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Alumot, E., Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Meidler, M., Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Holstein, P., Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Herzberg, M., Ichilov Hospital, Tel Aviv, Israel
Tolerance and acceptable daily intake of ethylene dichloride in the chicken diet
Leghorn chickens of both sexes were fed mash fumigated with ethylene dichloride (1,2-dichloroethane) for 2 yr. Growth, performance of layers, fertility, reproduction and biochemical tests served as criteria for establishing the no-effect levels. Ethylene dichloride did not affect the growth, semen characteristics or fertility of the chickens, and the results of serum analyses on treated chickens did not differ from those on controls. Both fumigant levels, 250 and 500 ppm in the mash, caused a moderate but persistent decrease in egg weight from month 4 of the laying period. Egg production was affected only by the higher level of fumigant. A tolerance of 100 ppm and an acceptable daily intake of 5 mg/kg body weight seem to be justified for laying hens. For growing chicks and cocks the tolerance and acceptable daily intake are the same as those previously determined for rats, namely 250 ppm and 25 mg/kg, respectively. © 1976 Pergamon Press.
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