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פותח על ידי קלירמאש פתרונות בע"מ -
Activation of octopaminergic receptors by essential oil constituents isolated from aromatic plants: Possible mode of action against insect pests
Year:
2002
Source of publication :
Pest Management Science
Authors :
גלעדי, קרינה
;
.
דמצ'נקו, נטלי
;
.
קוסטיוקובסקי, משה
;
.
רפאלי, עדה
;
.
שעיה, אלי
;
.
Volume :
58
Co-Authors:
Kostyukovsky, M., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Rafaeli, A., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Gileadi, C., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Demchenko, N., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Shaaya, E., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Facilitators :
From page:
1101
To page:
1106
(
Total pages:
6
)
Abstract:
As a result of screening a large number of essential oils from Israeli aromatic plants and their biologically active constituents, we isolated two oils with high activity against several stored-product insects. In this study the effect of these compounds on the acetylcholinesterase and the octopamine systems in insects was studied in order to elucidate their mode of action. Inhibition of acetyl-cholinesterase activity in vitro was evident only at high concentrations (10-3 M) and could not account effectively for the low-dose mortality for some stored-product insects observed in vivo. However, the essential oil constituents were found to cause a significant increase in the levels of the intracellular messenger, cyclic AMP of abdominal epidermal tissue in the model insect, Helicoverpa armigera Hübn. The effect was significant even at low, physiological concentrations (10-8 M) when tested directly on abdominal epidermal tissue preparations in vitro. This intracellular response was found to resemble closely the significant increases in the levels of the cyclic AMP of abdominal epidermal tissue due to treatment with the neurotransmitter/neuromodulator, octopamine. Subsequent treatment with the octopaminergic antagonist, phentolamine, effectively inhibited the cyclic AMP levels induced by essential oil treatment, indicating possible competitive activation of octopaminergic receptors by essential oil constituents. © 2002 Society of Chemical Industry.
Note:
Related Files :
Animals
essential oils
insects
Lepidoptera
metabolism
pest control
Plants
עוד תגיות
תוכן קשור
More details
DOI :
10.1002/ps.548
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר מתוך כינוס
;
.
Language:
אנגלית
Editors' remarks:
ID:
31682
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:04
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Scientific Publication
Activation of octopaminergic receptors by essential oil constituents isolated from aromatic plants: Possible mode of action against insect pests
58
Kostyukovsky, M., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Rafaeli, A., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Gileadi, C., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Demchenko, N., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Shaaya, E., ARO, Volcani Center, Institute for Technology and Storage of Agricultural Products, PO Box 6, Bet Dagan 50250, Israel
Activation of octopaminergic receptors by essential oil constituents isolated from aromatic plants: Possible mode of action against insect pests
As a result of screening a large number of essential oils from Israeli aromatic plants and their biologically active constituents, we isolated two oils with high activity against several stored-product insects. In this study the effect of these compounds on the acetylcholinesterase and the octopamine systems in insects was studied in order to elucidate their mode of action. Inhibition of acetyl-cholinesterase activity in vitro was evident only at high concentrations (10-3 M) and could not account effectively for the low-dose mortality for some stored-product insects observed in vivo. However, the essential oil constituents were found to cause a significant increase in the levels of the intracellular messenger, cyclic AMP of abdominal epidermal tissue in the model insect, Helicoverpa armigera Hübn. The effect was significant even at low, physiological concentrations (10-8 M) when tested directly on abdominal epidermal tissue preparations in vitro. This intracellular response was found to resemble closely the significant increases in the levels of the cyclic AMP of abdominal epidermal tissue due to treatment with the neurotransmitter/neuromodulator, octopamine. Subsequent treatment with the octopaminergic antagonist, phentolamine, effectively inhibited the cyclic AMP levels induced by essential oil treatment, indicating possible competitive activation of octopaminergic receptors by essential oil constituents. © 2002 Society of Chemical Industry.
Scientific Publication
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