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פותח על ידי קלירמאש פתרונות בע"מ -
Multiple sites for double-strand breaks in whole meiotic chromosomes of Saccharomyces cerevisiae
Year:
1992
Source of publication :
eLife
Authors :
שרמן, עמיר
;
.
Volume :
11
Co-Authors:
Zenvirth, D., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Arbel, T., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Sherman, A., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Goldway, M., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Klein, S., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Simchen, G., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Facilitators :
From page:
3441
To page:
3447
(
Total pages:
7
)
Abstract:
We present a scheme for locating double-strand breaks (DSBs) in meiotic chromosomes of Saccharomyces cerevisiae, based on the separation of large DNA molecules by pulsed field gel electrophoresis. Using a rad50S mutant, in which DSBs are not processed, we show that DSBs are widely induced in S.cerevisiae chromosomes during meiosis. Some of the DSBs accumulate at certain preferred sites. We present general profiles of DSBs in chromosomes III, V, VI and VII. A map of the 12 preferred sites on chromosome III is presented. At least some of these sites correlate with known 'hot spots' for meiotic recombination. The data are discussed in view of current models of meiotic recombination and chromosome segregation.
Note:
Related Files :
chromosome map
chromosome mapping
Chromosomes
Double-strand breaks
double stranded DNA
genetic recombination
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
31692
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:04
You may also be interested in
Scientific Publication
Multiple sites for double-strand breaks in whole meiotic chromosomes of Saccharomyces cerevisiae
11
Zenvirth, D., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Arbel, T., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Sherman, A., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Goldway, M., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Klein, S., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Simchen, G., Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Multiple sites for double-strand breaks in whole meiotic chromosomes of Saccharomyces cerevisiae
We present a scheme for locating double-strand breaks (DSBs) in meiotic chromosomes of Saccharomyces cerevisiae, based on the separation of large DNA molecules by pulsed field gel electrophoresis. Using a rad50S mutant, in which DSBs are not processed, we show that DSBs are widely induced in S.cerevisiae chromosomes during meiosis. Some of the DSBs accumulate at certain preferred sites. We present general profiles of DSBs in chromosomes III, V, VI and VII. A map of the 12 preferred sites on chromosome III is presented. At least some of these sites correlate with known 'hot spots' for meiotic recombination. The data are discussed in view of current models of meiotic recombination and chromosome segregation.
Scientific Publication
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