חיפוש מתקדם
PLoS ONE
Sela, N., Department of Human Molecular Genetics, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Department of Botanic, Faculty of Biology, Ludwig-Maximilians-University, Munich, Germany
Mersch, B., Department of Molecular Biophysics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Hotz-Wagenblatt, A., Department of Molecular Biophysics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Ast, G., Department of Human Molecular Genetics, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Insertion of transposed elements within mammalian genes is thought to be an important contributor to mammalian evolution and speciation. Insertion of transposed elements into introns can lead to their activation as alternatively spliced cassette exons, an event called exonization. Elucidation of the evolutionary constraints that have shaped fixation of transposed elements within human and mouse protein coding genes and subsequent exonization is important for understanding of how the exonization process has affected transcriptome and proteome complexities. Here we show that exonization of transposed elements is biased towards the beginning of the coding sequence in both human and mouse genes. Analysis of single nucleotide polymorphisms (SNPs) revealed that exonization of transposed elements can be population-specific, implying that exonizations may enhance divergence and lead to speciation. SNP density analysis revealed differences between Alu and other transposed elements. Finally, we identified cases of primate-specific Alu elements that depend on RNA editing for their exonization. These results shed light on TE fixation and the exonization process within human and mouse genes. © 2010 Sela et al.
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הספר "אוצר וולקני"
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תנאי שימוש
Characteristics of transposable element exonization within human and mouse
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Sela, N., Department of Human Molecular Genetics, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Department of Botanic, Faculty of Biology, Ludwig-Maximilians-University, Munich, Germany
Mersch, B., Department of Molecular Biophysics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Hotz-Wagenblatt, A., Department of Molecular Biophysics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Ast, G., Department of Human Molecular Genetics, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Characteristics of transposable element exonization within human and mouse
Insertion of transposed elements within mammalian genes is thought to be an important contributor to mammalian evolution and speciation. Insertion of transposed elements into introns can lead to their activation as alternatively spliced cassette exons, an event called exonization. Elucidation of the evolutionary constraints that have shaped fixation of transposed elements within human and mouse protein coding genes and subsequent exonization is important for understanding of how the exonization process has affected transcriptome and proteome complexities. Here we show that exonization of transposed elements is biased towards the beginning of the coding sequence in both human and mouse genes. Analysis of single nucleotide polymorphisms (SNPs) revealed that exonization of transposed elements can be population-specific, implying that exonizations may enhance divergence and lead to speciation. SNP density analysis revealed differences between Alu and other transposed elements. Finally, we identified cases of primate-specific Alu elements that depend on RNA editing for their exonization. These results shed light on TE fixation and the exonization process within human and mouse genes. © 2010 Sela et al.
Scientific Publication
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