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Cell
Kassir, Y., Department of Genetics The Hebrew University Jerusalem, 91904, Israel
Granot, D., Department of Genetics The Hebrew University Jerusalem, 91904, Israel
Simchen, G., Department of Genetics The Hebrew University Jerusalem, 91904, Israel
IMEI (inducer of MEiosis) was cloned due to its high copy number effect: it enabled MAT insufficient strains to undergo meiosis. Disruption of IMEI results in a recessive Spo- phenotype. Diploids homozygous for the two mutations ime1-0, rmel-1 are also meios deficient. We conclude that IME1 is a positive regultor of meiosis that normally is repressed by RME1. RME is repressed by a complex of MATal and MATα2 gene products. IME1 is also regulated by the environment: no transcripts could be detected in glucose growing cells, in contrast to acetate growing cell. Starvation for nitrogen further induced (6- to 8-fold) transcription of IME1, but, as expected, the induction was found only in MATa/MATα or rmel-l/rme1-1 diploids. Furthermore, the IME1 multicopy plasmids promoted sporulation in rich media. © 1988.
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IME1, a positive regulator gene of meiosis in S. cerevisiae
52
Kassir, Y., Department of Genetics The Hebrew University Jerusalem, 91904, Israel
Granot, D., Department of Genetics The Hebrew University Jerusalem, 91904, Israel
Simchen, G., Department of Genetics The Hebrew University Jerusalem, 91904, Israel
IME1, a positive regulator gene of meiosis in S. cerevisiae
IMEI (inducer of MEiosis) was cloned due to its high copy number effect: it enabled MAT insufficient strains to undergo meiosis. Disruption of IMEI results in a recessive Spo- phenotype. Diploids homozygous for the two mutations ime1-0, rmel-1 are also meios deficient. We conclude that IME1 is a positive regultor of meiosis that normally is repressed by RME1. RME is repressed by a complex of MATal and MATα2 gene products. IME1 is also regulated by the environment: no transcripts could be detected in glucose growing cells, in contrast to acetate growing cell. Starvation for nitrogen further induced (6- to 8-fold) transcription of IME1, but, as expected, the induction was found only in MATa/MATα or rmel-l/rme1-1 diploids. Furthermore, the IME1 multicopy plasmids promoted sporulation in rich media. © 1988.
Scientific Publication
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