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פותח על ידי קלירמאש פתרונות בע"מ -
Natriuretic peptide receptors regulate endothelin synthesis and release from parathyroid cells
Year:
1991
Authors :
הורביץ, שמואל
;
.
פינס, מרק
;
.
Volume :
88
Co-Authors:
De Feo, M.L., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Bartolini, O., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Orlando, C., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Maggi, M., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Serio, M., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Fujii, Y., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Sakaguchi, K., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Aurbach, G.D., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Brandi, M.L., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Facilitators :
From page:
6496
To page:
6500
(
Total pages:
5
)
Abstract:
Cloned rat parathyroid cells (PTr cell line) that produce parathyroid hormone-related peptide plus endothelin 1 and primary cultures of human parathyroid cells were tested for growth and differentiation responses to atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). High- and low-affinity binding sites for ANP were found on PTr cells; BNP appeared to bind to the same receptors with similar affinities. Either ANP or BNP stimulated production of cGMP and caused a 30% decrease in Na+-K+-Cl- cotransport. Each peptide increased synthesis and secretion of endothelin 1 by PTr cells in a dose-dependent fashion, but cell growth was not affected. Human parathyroid cells (normal and pathological) also responded to ANP or BNP with an increase in cGMP production. The finding of receptors for natriuretic hormones on parathyroid cells with consequent effects on release of endothelin 1 might be of relevance in understanding the clinical association between hyperparathyroidism and hypertension.
Note:
Related Files :
Animal
animal cell
Hypertension
Na(+)-K(+)-Exchanging ATPase
Natriuretic Peptide, Brain
Rubidium
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
31730
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:04
You may also be interested in
Scientific Publication
Natriuretic peptide receptors regulate endothelin synthesis and release from parathyroid cells
88
De Feo, M.L., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Bartolini, O., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Orlando, C., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Maggi, M., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Serio, M., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Fujii, Y., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Sakaguchi, K., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Aurbach, G.D., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Brandi, M.L., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Natriuretic peptide receptors regulate endothelin synthesis and release from parathyroid cells
Cloned rat parathyroid cells (PTr cell line) that produce parathyroid hormone-related peptide plus endothelin 1 and primary cultures of human parathyroid cells were tested for growth and differentiation responses to atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). High- and low-affinity binding sites for ANP were found on PTr cells; BNP appeared to bind to the same receptors with similar affinities. Either ANP or BNP stimulated production of cGMP and caused a 30% decrease in Na+-K+-Cl- cotransport. Each peptide increased synthesis and secretion of endothelin 1 by PTr cells in a dose-dependent fashion, but cell growth was not affected. Human parathyroid cells (normal and pathological) also responded to ANP or BNP with an increase in cGMP production. The finding of receptors for natriuretic hormones on parathyroid cells with consequent effects on release of endothelin 1 might be of relevance in understanding the clinical association between hyperparathyroidism and hypertension.
Scientific Publication
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