אסיף מאגר המחקר החקלאי

Natriuretic peptide receptors regulate endothelin synthesis and release from parathyroid cells

Year:

1991

Source of publication :

Authors :

Volume :

88

Co-Authors:

De Feo, M.L., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Bartolini, O., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Orlando, C., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Maggi, M., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Serio, M., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Fujii, Y., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Sakaguchi, K., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Aurbach, G.D., Metabolic Diseases Branch, Natl. Inst. Diabet. Digest. K., National Institutes of Health, Bethesda, MD 20892, United States
Brandi, M.L., Dept. of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy

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Abstract:

Cloned rat parathyroid cells (PTr cell line) that produce parathyroid hormone-related peptide plus endothelin 1 and primary cultures of human parathyroid cells were tested for growth and differentiation responses to atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). High- and low-affinity binding sites for ANP were found on PTr cells; BNP appeared to bind to the same receptors with similar affinities. Either ANP or BNP stimulated production of cGMP and caused a 30% decrease in Na+-K+-Cl- cotransport. Each peptide increased synthesis and secretion of endothelin 1 by PTr cells in a dose-dependent fashion, but cell growth was not affected. Human parathyroid cells (normal and pathological) also responded to ANP or BNP with an increase in cGMP production. The finding of receptors for natriuretic hormones on parathyroid cells with consequent effects on release of endothelin 1 might be of relevance in understanding the clinical association between hyperparathyroidism and hypertension.

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