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פותח על ידי קלירמאש פתרונות בע"מ -
Paternity validation and estimation of genotyping error rate for the BovineSNP50 BeadChip
Year:
2010
Source of publication :
Animal Genetics
Authors :
ולר, יהודה
;
.
סרוסי, אייל
;
.
רון, מיכה
;
.
Volume :
41
Co-Authors:
Weller, J.I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Glick, G., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot 76100, Israel
Ezra, E., Israel Cattle Breeders Association, Caesaria Industrial Park 38900, Israel
Zeron, Y., Sion, AI Institute, Shikmim 79800, Israel
Seroussi, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
551
To page:
553
(
Total pages:
3
)
Abstract:
Incorrect paternity assignment in cattle can have a major effect on rates of genetic gain. Of the 576 Israeli Holstein bulls genotyped by the BovineSNP50 BeadChip, there were 204 bulls for which the father was also genotyped. The results of 38 828 valid single nucleotide polymorphisms (SNPs) were used to validate paternity, determine the genotyping error rates and determine criteria enabling deletion of defective SNPs from further analysis. Based on the criterion of >2% conflicts between the genotype of the putative sire and son, paternity was rejected for seven bulls (3.5%). The remaining bulls had fewer conflicts by one or two orders of magnitude. Excluding these seven bulls, all other discrepancies between sire and son genotypes are assumed to be caused by genotyping mistakes. The frequency of discrepancies was >0.07 for nine SNPs, and >0.025 for 81 SNPs. The overall frequency of discrepancies was reduced from 0.00017 to 0.00010 after deletion of these 81 SNPs, and the total expected fraction of genotyping errors was estimated to be 0.05%. Paternity of bulls that are genotyped for genomic selection may be verified or traced against candidate sires at virtually no additional cost. © 2010 Stichting International Foundation for Animal Genetics.
Note:
Related Files :
Animal
animal disease
Animals
Bos
cattle
dairy cattle
Genetics
genotyping error rate
Male
עוד תגיות
תוכן קשור
More details
DOI :
10.1111/j.1365-2052.2010.02035.x
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
31880
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:06
You may also be interested in
Scientific Publication
Paternity validation and estimation of genotyping error rate for the BovineSNP50 BeadChip
41
Weller, J.I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Glick, G., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot 76100, Israel
Ezra, E., Israel Cattle Breeders Association, Caesaria Industrial Park 38900, Israel
Zeron, Y., Sion, AI Institute, Shikmim 79800, Israel
Seroussi, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Paternity validation and estimation of genotyping error rate for the BovineSNP50 BeadChip
Incorrect paternity assignment in cattle can have a major effect on rates of genetic gain. Of the 576 Israeli Holstein bulls genotyped by the BovineSNP50 BeadChip, there were 204 bulls for which the father was also genotyped. The results of 38 828 valid single nucleotide polymorphisms (SNPs) were used to validate paternity, determine the genotyping error rates and determine criteria enabling deletion of defective SNPs from further analysis. Based on the criterion of >2% conflicts between the genotype of the putative sire and son, paternity was rejected for seven bulls (3.5%). The remaining bulls had fewer conflicts by one or two orders of magnitude. Excluding these seven bulls, all other discrepancies between sire and son genotypes are assumed to be caused by genotyping mistakes. The frequency of discrepancies was >0.07 for nine SNPs, and >0.025 for 81 SNPs. The overall frequency of discrepancies was reduced from 0.00017 to 0.00010 after deletion of these 81 SNPs, and the total expected fraction of genotyping errors was estimated to be 0.05%. Paternity of bulls that are genotyped for genomic selection may be verified or traced against candidate sires at virtually no additional cost. © 2010 Stichting International Foundation for Animal Genetics.
Scientific Publication
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