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פותח על ידי קלירמאש פתרונות בע"מ -
Proteins M6 and F1 are required for efficient invasion of Group A streptococci into cultured epithelial cells
Year:
1997
Authors :
סלע, שלמה
;
.
Volume :
418
Co-Authors:
Jadoun, J., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Burstein, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Hanski, E., Department of Clinical Microbiology, Hebrew University, Hadassah Medical School, Jerusalem 91010, Israel
Sela, S., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Facilitators :
From page:
511
To page:
515
(
Total pages:
5
)
Abstract:
Group A streptococci were recently shown to be capable of invading human epithelial cell monolayers. Cell invasion might be an important virulence trait of streptococci that enable the pathogen to gain entry into deeper tissues after initial binding to host cells. Nothing is known concerning the nature of streptococcal components that mediate invasion. Using isogenic mutants of strain JRS4 that are defective in the expression of either M6 protein or protein F1, or both proteins, it was demonstrated that both adhesins are required for efficient invasion. Furthermore, expression of protein F1 on the surface of a non-invasive strain rendered the latter invasive, suggesting that protein F1 is directly involved in the invasion process.
Note:
Related Files :
Bacterial Outer Membrane Proteins
cell invasion
Conference paper
human cell
mutation
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר מתוך כינוס
;
.
Language:
אנגלית
Editors' remarks:
ID:
31901
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:06
Scientific Publication
Proteins M6 and F1 are required for efficient invasion of Group A streptococci into cultured epithelial cells
418
Jadoun, J., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Burstein, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Hanski, E., Department of Clinical Microbiology, Hebrew University, Hadassah Medical School, Jerusalem 91010, Israel
Sela, S., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Proteins M6 and F1 are required for efficient invasion of Group A streptococci into cultured epithelial cells
Group A streptococci were recently shown to be capable of invading human epithelial cell monolayers. Cell invasion might be an important virulence trait of streptococci that enable the pathogen to gain entry into deeper tissues after initial binding to host cells. Nothing is known concerning the nature of streptococcal components that mediate invasion. Using isogenic mutants of strain JRS4 that are defective in the expression of either M6 protein or protein F1, or both proteins, it was demonstrated that both adhesins are required for efficient invasion. Furthermore, expression of protein F1 on the surface of a non-invasive strain rendered the latter invasive, suggesting that protein F1 is directly involved in the invasion process.
Scientific Publication
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