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פותח על ידי קלירמאש פתרונות בע"מ -
Estimation of Candidate Gene Effects in Dairy Cattle Populations
Year:
1998
Source of publication :
Journal of Dairy Science
Authors :
ולר, יהודה
;
.
Volume :
81
Co-Authors:
Israel, C., Hebrew University of Jerusalem, Jerusalem 91904, Israel
Weller, J.I., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
1653
To page:
1662
(
Total pages:
10
)
Abstract:
Standard programs for animal models can be modified to include the effect of a candidate gene, even if only a fraction of the population is genotyped. The elements of the incidence matrix for this effect is 0 or 1 for genotyped individuals and for the probabilities of the candidate gene genotypes for individuals that were not genotyped. The effects of a diallelic candidate gene that were estimated by this method were compared on simulated populations with three alternative estimation methods: analysis of genetic evaluations, yield deviations, and daughter yield deviations, all of which were derived from a standard animal model. The bases of comparison were mean squared error and bias. Four types of experimental designs were considered: genotyping sires only, genotyping cows only, genotyping half of the cows but no sires, and genotyping half of the sires and half of the cows. The estimates that were derived from the three alternative methods all underestimated the simulated effects. The genetic evaluations were more biased than were the yield deviations and the daughter yield deviations. The proposed method was significantly biased only for the design in which half of the daughters, but no sires, were genotyped. Bias and mean squared errors were always lowest by the proposed method.
Note:
Related Files :
Animal
Animals
breeding
cattle
Female
genetic markers
Genetics
lactation
Male
phenotype
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
31964
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:06
You may also be interested in
Scientific Publication
Estimation of Candidate Gene Effects in Dairy Cattle Populations
81
Israel, C., Hebrew University of Jerusalem, Jerusalem 91904, Israel
Weller, J.I., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Estimation of Candidate Gene Effects in Dairy Cattle Populations
Standard programs for animal models can be modified to include the effect of a candidate gene, even if only a fraction of the population is genotyped. The elements of the incidence matrix for this effect is 0 or 1 for genotyped individuals and for the probabilities of the candidate gene genotypes for individuals that were not genotyped. The effects of a diallelic candidate gene that were estimated by this method were compared on simulated populations with three alternative estimation methods: analysis of genetic evaluations, yield deviations, and daughter yield deviations, all of which were derived from a standard animal model. The bases of comparison were mean squared error and bias. Four types of experimental designs were considered: genotyping sires only, genotyping cows only, genotyping half of the cows but no sires, and genotyping half of the sires and half of the cows. The estimates that were derived from the three alternative methods all underestimated the simulated effects. The genetic evaluations were more biased than were the yield deviations and the daughter yield deviations. The proposed method was significantly biased only for the design in which half of the daughters, but no sires, were genotyped. Bias and mean squared errors were always lowest by the proposed method.
Scientific Publication
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