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Nucleic Acids Research
Tuller, T., Faculty of Mathematics and Computer Science, Weizmann Institute of Science, Rehovot, Israel, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Girshovich, Y., Blavatnik School of Computer Science, Israel
Sella, Y., Blavatnik School of Computer Science, Israel
Kreimer, A., Blavatnik School of Computer Science, Israel
Freilich, S., Blavatnik School of Computer Science, Israel, School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
Kupiec, M., Department of Molecular Microbiology and Biotechnology, Israel
Gophna, U., Department of Molecular Microbiology and Biotechnology, Israel
Ruppin, E., Blavatnik School of Computer Science, Israel, School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
Horizontal gene transfer (HGT) is a major force in microbial evolution. Previous studies have suggested that a variety of factors, including restricted recombination and toxicity of foreign gene products, may act as barriers to the successful integration of horizontally transferred genes. This study identifies an additional central barrier to HGT - the lack of co-adaptation between the codon usage of the transferred gene and the tRNA pool of the recipient organism. Analyzing the genomic sequences of more than 190 microorganisms and the HGT events that have occurred between them, we show that the number of genes that were horizontally transferred between organisms is positively correlated with the similarity between their tRNA pools. Those genes that are better adapted to the tRNA pools of the target genomes tend to undergo more frequent HGT. At the community (or environment) level, organisms that share a common ecological niche tend to have similar tRNA pools. These results remain significant after controlling for diverse ecological and evolutionary parameters. Our analysis demonstrates that there are bi-directional associations between the similarity in the tRNA pools of organisms and the number of HGT events occurring between them. Similar tRNA pools between a donor and a host tend to increase the probability that a horizontally acquired gene will become fixed in its new genome. Our results also suggest that frequent HGT may be a homogenizing force that increases the similarity in the tRNA pools of organisms within the same community. © 2011 The Author(s).
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תנאי שימוש
Association between translation efficiency and horizontal gene transfer within microbial communities
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Tuller, T., Faculty of Mathematics and Computer Science, Weizmann Institute of Science, Rehovot, Israel, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Girshovich, Y., Blavatnik School of Computer Science, Israel
Sella, Y., Blavatnik School of Computer Science, Israel
Kreimer, A., Blavatnik School of Computer Science, Israel
Freilich, S., Blavatnik School of Computer Science, Israel, School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
Kupiec, M., Department of Molecular Microbiology and Biotechnology, Israel
Gophna, U., Department of Molecular Microbiology and Biotechnology, Israel
Ruppin, E., Blavatnik School of Computer Science, Israel, School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
Association between translation efficiency and horizontal gene transfer within microbial communities
Horizontal gene transfer (HGT) is a major force in microbial evolution. Previous studies have suggested that a variety of factors, including restricted recombination and toxicity of foreign gene products, may act as barriers to the successful integration of horizontally transferred genes. This study identifies an additional central barrier to HGT - the lack of co-adaptation between the codon usage of the transferred gene and the tRNA pool of the recipient organism. Analyzing the genomic sequences of more than 190 microorganisms and the HGT events that have occurred between them, we show that the number of genes that were horizontally transferred between organisms is positively correlated with the similarity between their tRNA pools. Those genes that are better adapted to the tRNA pools of the target genomes tend to undergo more frequent HGT. At the community (or environment) level, organisms that share a common ecological niche tend to have similar tRNA pools. These results remain significant after controlling for diverse ecological and evolutionary parameters. Our analysis demonstrates that there are bi-directional associations between the similarity in the tRNA pools of organisms and the number of HGT events occurring between them. Similar tRNA pools between a donor and a host tend to increase the probability that a horizontally acquired gene will become fixed in its new genome. Our results also suggest that frequent HGT may be a homogenizing force that increases the similarity in the tRNA pools of organisms within the same community. © 2011 The Author(s).
Scientific Publication
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