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פותח על ידי קלירמאש פתרונות בע"מ -
Coffee polyphenols protect human plasma from postprandial carbonyl modifications
Year:
2013
Authors :
קנר, יוסף
;
.
Volume :
57
Co-Authors:
Sirota, R., The Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Gorelik, S., The Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Harris, R., The Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Kohen, R., The Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Kanner, J., Department of Food Science, ARO, Volcani Center, Bet Dagan, Israel
Facilitators :
From page:
916
To page:
919
(
Total pages:
4
)
Abstract:
The antioxidant capability of coffee polyphenols to inhibit red-meat lipid peroxidation in stomach medium and absorption into blood of malondialdehyde (MDA) in humans was studied. Roasted-ground coffee polyphenols that were found to inhibit lipid peroxidation in stomach medium are 2- to 5-fold more efficient antioxidant than those found in instant coffee. Human plasma from ten volunteers analyzed after a meal of red-meat cutlets (250 g) revealed a rapid accumulation of MDA. The accumulation of MDA in human plasma modified low-density lipoprotein is known to trigger atherogenesis. Consumption of 200 mL roasted coffee by ten volunteers during a meal of red-meat cutlets, resulted after 2 and 4 h in the inhibition by 80 and 50%, respectively, of postprandial plasma MDA absorption. The results obtained in vitro simulated stomach model on MDA accumulation were predictive for the amount of MDA absorbed into circulating human plasma, in vivo. Timing the consumption of coffee during the meals may make it a very active functional food. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Note:
Related Files :
Animal
Animals
antioxidants
Blood
cattle
chemistry
drug effect
lipid peroxidation
Lipoproteins, LDL
malonaldehyde
meat
metabolism
עוד תגיות
תוכן קשור
More details
DOI :
10.1002/mnfr.201200557
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
32030
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:07
Scientific Publication
Coffee polyphenols protect human plasma from postprandial carbonyl modifications
57
Sirota, R., The Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Gorelik, S., The Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Harris, R., The Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Kohen, R., The Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Kanner, J., Department of Food Science, ARO, Volcani Center, Bet Dagan, Israel
Coffee polyphenols protect human plasma from postprandial carbonyl modifications
The antioxidant capability of coffee polyphenols to inhibit red-meat lipid peroxidation in stomach medium and absorption into blood of malondialdehyde (MDA) in humans was studied. Roasted-ground coffee polyphenols that were found to inhibit lipid peroxidation in stomach medium are 2- to 5-fold more efficient antioxidant than those found in instant coffee. Human plasma from ten volunteers analyzed after a meal of red-meat cutlets (250 g) revealed a rapid accumulation of MDA. The accumulation of MDA in human plasma modified low-density lipoprotein is known to trigger atherogenesis. Consumption of 200 mL roasted coffee by ten volunteers during a meal of red-meat cutlets, resulted after 2 and 4 h in the inhibition by 80 and 50%, respectively, of postprandial plasma MDA absorption. The results obtained in vitro simulated stomach model on MDA accumulation were predictive for the amount of MDA absorbed into circulating human plasma, in vivo. Timing the consumption of coffee during the meals may make it a very active functional food. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Scientific Publication
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