Co-Authors:
Folman, Y., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, NewLos Angelesington, CA, 90033, United States, Volcani Institute of Agricultural Research, Bet-Dagan, Israel
Sowell, J.G., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, NewLos Angelesington, CA, 90033, United States
Eik-Nes, K.B., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, NewLos Angelesington, CA, 90033, United States
Abstract:
5α-Dihydrotestosterone (DHT) was extracted, separated and identified from testes of mature rats. When teased preparations of testicular tissue, levator ani or thigh muscle were incubated with 3H-testosterone (T) and an NADPH generating system, 3H-DHT could be detected. Teased testicular tissue produced more 3H-DHT from 3H-T than homogenized tissue and the rates of this conversion in teased testicular tissue were the same in incubations carried out at 33 C or at 37 C. Testes of immature rats formed larger quantities of 3H-DHT and other 5a-reduced metabolites of 3H-T than testes of mature animals. FSH tended to stimulate testicular production of 3H-DHT from 3H-T only when administered to the rats prior to removal of the testes. Testes from rats injected with hCG formed less 3H-DHT from 3H-T than testes from control animals. This effect was also observed when hCG was added to the incubation medium. LH (ICSH) did not have an effect on synthesis of DHT from T at the doses tested. When testicular tissue was incubated with 3H-DHT as the substrate, the main 3H-metabolite was androstanediol. © 1972 by The Endocrine Society.
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