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פותח על ידי קלירמאש פתרונות בע"מ -
A complete genome scan of the Israeli Holstein population for quantitative trait loci by a daughter design
Year:
2004
Source of publication :
Journal of Dairy Science
Authors :
אלוס, אורית
;
.
כהן, י'
;
.
רייס, ו'
;
.
Volume :
87
Co-Authors:
Ron, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Feldmesser, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Golik, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Tager-Cohen, I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Kliger, D., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Reiss, V., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Domochovsky, R., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Alus, O., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Ezra, E., Israel Cattle Breeders Association, Caesaria Industrial Park, Caesaria 38900, Israel
Weller, J.I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
476
To page:
490
(
Total pages:
15
)
Abstract:
Eleven Israeli Holstein families including 5221 cows were analyzed by a daughter design for eight economic traits: milk, fat and protein production, fat and protein percentage, somatic cell score (SCS), herd-life, and female fertility. The cows were genotyped for 73 microsatellites with maximum spacing between markers of 53 cM. There were 86,304 informative genotypes. Preliminary analysis was by ANOVA of each trait, with the marker effect nested within sire. Significance was determined by controlling the false discovery rate at 0.4, after excluding markers with genome-wide significance for at least a single trait, and traits without any significant effects at this level. Thus, four markers on chromosomes 6 and 14 and female fertility were excluded. There remained 40 significant marker-trait combinations, and it is expected that 24 of these are true effects. To perform interval mapping for the families with significant contrasts, 21 additional markers were genotyped on chromosomes 2, 7, and 27. The bootstrap confidence intervals for gene effect did not include zero for protein percent on chromosome 2 and fat yield, protein yield, and SCS on chromosome 7. Quantitative trait locus heterozygosity was 33%, which is consistent with the hypothesis that only two alleles are segregating with unequal allele frequency. © American Dairy Science Association, 2004.
Note:
Related Files :
Animal
Animals
breeding
cattle
chromosome mapping
Female
Genetics
Israel
Male
milk
עוד תגיות
תוכן קשור
More details
DOI :
10.3168/jds.S0022-0302(04)73187-2
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
32311
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:08
Scientific Publication
A complete genome scan of the Israeli Holstein population for quantitative trait loci by a daughter design
87
Ron, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Feldmesser, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Golik, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Tager-Cohen, I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Kliger, D., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Reiss, V., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Domochovsky, R., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Alus, O., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Ezra, E., Israel Cattle Breeders Association, Caesaria Industrial Park, Caesaria 38900, Israel
Weller, J.I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
A complete genome scan of the Israeli Holstein population for quantitative trait loci by a daughter design
Eleven Israeli Holstein families including 5221 cows were analyzed by a daughter design for eight economic traits: milk, fat and protein production, fat and protein percentage, somatic cell score (SCS), herd-life, and female fertility. The cows were genotyped for 73 microsatellites with maximum spacing between markers of 53 cM. There were 86,304 informative genotypes. Preliminary analysis was by ANOVA of each trait, with the marker effect nested within sire. Significance was determined by controlling the false discovery rate at 0.4, after excluding markers with genome-wide significance for at least a single trait, and traits without any significant effects at this level. Thus, four markers on chromosomes 6 and 14 and female fertility were excluded. There remained 40 significant marker-trait combinations, and it is expected that 24 of these are true effects. To perform interval mapping for the families with significant contrasts, 21 additional markers were genotyped on chromosomes 2, 7, and 27. The bootstrap confidence intervals for gene effect did not include zero for protein percent on chromosome 2 and fat yield, protein yield, and SCS on chromosome 7. Quantitative trait locus heterozygosity was 33%, which is consistent with the hypothesis that only two alleles are segregating with unequal allele frequency. © American Dairy Science Association, 2004.
Scientific Publication
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