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פותח על ידי קלירמאש פתרונות בע"מ -
Revival of the extinct balm of gilead in Israel: Studying its anti-cancer activity
Year:
2015
Source of publication :
Acta Horticulturae
Authors :
בן-יהושע, שמשון
;
.
דודאי, נתיב
;
.
Volume :
1088
Co-Authors:
Yehoshua, S.B., Agricultural Research Organization, Bet-Dagan, Israel
Ofir, R., Dead Sea and Arava Science Center, Dead Sea, Israel, Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Rachmilevitch, S., Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boquer Campus, Midreshet, Ben Gurion, Israel
Amiel, E., Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boquer Campus, Midreshet, Ben Gurion, Israel
Dudai, N., Unit of Medicinal and Aromatic Plants, Newe ya'Ar Research Center, Ramat Ishai, Israel
Soloway, E., Center for Sustainable Agriculture, Arava Institute for Environmental Studies, D.N. Hevel Eilot, Israel
Facilitators :
From page:
509
To page:
514
(
Total pages:
6
)
Abstract:
Among the most reputed ancient medical plants was the balm of Gilead known as the apharsemon, identified botanically as Commiphora gileadensis L. This plant originated in the Kingdom of Sheba on the south of the Arabian Peninsala. Apharsemon, known also as the Judean balsam, grew as an agricultural crop only around the Dead Sea Basin in antiquity and achieved fame by its highly reputed aroma and medical properties but has been extinct for many centuries. The resin of this crop was sold at a price twice its weight in gold, the highest price ever paid for an agricultural commodity. This ancient plant was investigated in this study for its anticancerous activity against cancer cell lines. The results obtained from ethanolbased extracts indicated that β-caryophyllene (trans-(1R,9S)-8-methylene-4,11,11- trimethylbicyclo(7.2.0)undec-4-ene) is a key component in the essential oil extracted from the balm of Gilead. β-Caryophyllene can be found in a variety of food and beverage products. In the current paper, we report that Commiphora gileadensis stem and leaf extracts as well as its essential oil have an anti-proliferative proapoptotic effect against tumor cells and not against normal cells. β- caryophyllene caused a potent induction of apoptosis accompanied by DNA ladder and caspase-3 catalytic activity in tumor cell lines. In summary, we showed that C. gileadensis plant contain an apoptosis inducer that acts, in a selective manner, against tumor cell lines and not against normal cells.
Note:
Related Files :
Anti-cancer agents
Commiphora gileadensis
Judean balsam
spices; medicinal plants; perfumes
traditional medicine
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
32322
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:08
You may also be interested in
Scientific Publication
Revival of the extinct balm of gilead in Israel: Studying its anti-cancer activity
1088
Yehoshua, S.B., Agricultural Research Organization, Bet-Dagan, Israel
Ofir, R., Dead Sea and Arava Science Center, Dead Sea, Israel, Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Rachmilevitch, S., Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boquer Campus, Midreshet, Ben Gurion, Israel
Amiel, E., Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boquer Campus, Midreshet, Ben Gurion, Israel
Dudai, N., Unit of Medicinal and Aromatic Plants, Newe ya'Ar Research Center, Ramat Ishai, Israel
Soloway, E., Center for Sustainable Agriculture, Arava Institute for Environmental Studies, D.N. Hevel Eilot, Israel
Revival of the extinct balm of gilead in Israel: Studying its anti-cancer activity
Among the most reputed ancient medical plants was the balm of Gilead known as the apharsemon, identified botanically as Commiphora gileadensis L. This plant originated in the Kingdom of Sheba on the south of the Arabian Peninsala. Apharsemon, known also as the Judean balsam, grew as an agricultural crop only around the Dead Sea Basin in antiquity and achieved fame by its highly reputed aroma and medical properties but has been extinct for many centuries. The resin of this crop was sold at a price twice its weight in gold, the highest price ever paid for an agricultural commodity. This ancient plant was investigated in this study for its anticancerous activity against cancer cell lines. The results obtained from ethanolbased extracts indicated that β-caryophyllene (trans-(1R,9S)-8-methylene-4,11,11- trimethylbicyclo(7.2.0)undec-4-ene) is a key component in the essential oil extracted from the balm of Gilead. β-Caryophyllene can be found in a variety of food and beverage products. In the current paper, we report that Commiphora gileadensis stem and leaf extracts as well as its essential oil have an anti-proliferative proapoptotic effect against tumor cells and not against normal cells. β- caryophyllene caused a potent induction of apoptosis accompanied by DNA ladder and caspase-3 catalytic activity in tumor cell lines. In summary, we showed that C. gileadensis plant contain an apoptosis inducer that acts, in a selective manner, against tumor cell lines and not against normal cells.
Scientific Publication
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