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פותח על ידי קלירמאש פתרונות בע"מ -
Control of cell proliferation by embryonal-origin factors
Year:
1996
Authors :
פינס, מרק
;
.
Volume :
35
Co-Authors:
Barnea, E.R., Soc. the Invest. of Early Pregnancy, Biospectrum Medical Corporation, Cherry Hill, NJ, United States, 1697 Lark Lane, Cherry Hill, NJ 08003, United States
Barnea, J.-D., Soc. the Invest. of Early Pregnancy, Biospectrum Medical Corporation, Cherry Hill, NJ, United States
Pines, M., Vulcani Institute, Rehoboth, Israel
Facilitators :
From page:
318
To page:
324
(
Total pages:
7
)
Abstract:
Embryogenesis can be paralleled and contrasted with cancerous cell proliferation; both embryogenesis and cancer are associated with extremely rapid cell proliferation. However, unlike cancer, embryogenesis is characterized by a delicate balance of proliferative and anti-proliferative processes. We have found two chromatographically separated fractions derived from human embryonal neural tissue extracts that significantly suppress the proliferation of human breast cancer cells. The reduction in cell number was time dependent, with maximal inhibition (70%) observed after 4 days of incubation while maintaining cell viability. The anti-proliferative effect was also evidenced by decreased [3H]-thymidine incorporation. Significant inhibition of proliferation of osteosarcoma, fibrosarcoma, and Balb/c 3T3 cell lines was also obtained with a low concentration of the active fractions. Embryonal factors inhibited mouse and rat cell lines, indicating cross-species effectiveness. The SDS-PAGE of the biologically active ~10.7 kDa region revealed several protein bands, while the biologically active ~4.5 kDa fraction contained only weakly stainable bands. Thus, the embryo contains factors that control the proliferation of malignant cells. These potent and possibly novel compounds should be investigated for their potential therapeutic role in cancer and other proliferative disorders.
Note:
Related Files :
Animals
breast cancer
Cancer
Cell Proliferation
Conference paper
Growth Substances
mice
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר מתוך כינוס
;
.
Language:
אנגלית
Editors' remarks:
ID:
32398
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:09
You may also be interested in
Scientific Publication
Control of cell proliferation by embryonal-origin factors
35
Barnea, E.R., Soc. the Invest. of Early Pregnancy, Biospectrum Medical Corporation, Cherry Hill, NJ, United States, 1697 Lark Lane, Cherry Hill, NJ 08003, United States
Barnea, J.-D., Soc. the Invest. of Early Pregnancy, Biospectrum Medical Corporation, Cherry Hill, NJ, United States
Pines, M., Vulcani Institute, Rehoboth, Israel
Control of cell proliferation by embryonal-origin factors
Embryogenesis can be paralleled and contrasted with cancerous cell proliferation; both embryogenesis and cancer are associated with extremely rapid cell proliferation. However, unlike cancer, embryogenesis is characterized by a delicate balance of proliferative and anti-proliferative processes. We have found two chromatographically separated fractions derived from human embryonal neural tissue extracts that significantly suppress the proliferation of human breast cancer cells. The reduction in cell number was time dependent, with maximal inhibition (70%) observed after 4 days of incubation while maintaining cell viability. The anti-proliferative effect was also evidenced by decreased [3H]-thymidine incorporation. Significant inhibition of proliferation of osteosarcoma, fibrosarcoma, and Balb/c 3T3 cell lines was also obtained with a low concentration of the active fractions. Embryonal factors inhibited mouse and rat cell lines, indicating cross-species effectiveness. The SDS-PAGE of the biologically active ~10.7 kDa region revealed several protein bands, while the biologically active ~4.5 kDa fraction contained only weakly stainable bands. Thus, the embryo contains factors that control the proliferation of malignant cells. These potent and possibly novel compounds should be investigated for their potential therapeutic role in cancer and other proliferative disorders.
Scientific Publication
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