נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Inhibitive effects of structurally modified azasteroids and related nitrogen containing steroids on insect growth and development
Year:
1975
Source of publication :
Lipids
Authors :
סבובודה, ג'יימס
;
.
Volume :
10
Co-Authors:
Thompson, M.J., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Serban, N.N., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Robbins, W.E., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Svoboda, J.A., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Shortino, T.J., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Dutky, S.R., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Cohen, C.F., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Facilitators :
From page:
615
To page:
622
(
Total pages:
8
)
Abstract:
A number of azasteroids and other nitrogen containing steroids with a modified nucleus or side chain were prepared and tested for their inhibitory effects on the growth and development of several species of insects. Structure-activity studies showed that compounds with a structurally related steroid nucleus and side chain were approximately equal in inhibitory activity for a particular species. The replacement of the tertiary amino group in the side chain of the 5β-steroid with other nitrogen substituents, such as nitro, cyano, acetylamino, or a quaternary ammonium salt, resulted in a considerable loss of inhibitive activity in the tobacco hornworm or the yellowfever mosquito. However, certain modifications of the azasteroid nucleus resulted in compounds that still retained high biological activity. As a result, a compound was synthesized that lacked the A and B rings of the steroid nucleus and that inhibited insect growth, molting, and metamorphosis and the Δ24-sterol reductase enzyme system of the tobacco hornworm. © 1975 American Oil Chemists' Society.
Note:
Related Files :
Animals
Development
Growth
insects
Lepidoptera
Oxidoreductases
Steroids
structure activity relation
Tribolium
עוד תגיות
תוכן קשור
More details
DOI :
10.1007/BF02532726
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
32521
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:10
Scientific Publication
Inhibitive effects of structurally modified azasteroids and related nitrogen containing steroids on insect growth and development
10
Thompson, M.J., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Serban, N.N., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Robbins, W.E., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Svoboda, J.A., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Shortino, T.J., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Dutky, S.R., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Cohen, C.F., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Inhibitive effects of structurally modified azasteroids and related nitrogen containing steroids on insect growth and development
A number of azasteroids and other nitrogen containing steroids with a modified nucleus or side chain were prepared and tested for their inhibitory effects on the growth and development of several species of insects. Structure-activity studies showed that compounds with a structurally related steroid nucleus and side chain were approximately equal in inhibitory activity for a particular species. The replacement of the tertiary amino group in the side chain of the 5β-steroid with other nitrogen substituents, such as nitro, cyano, acetylamino, or a quaternary ammonium salt, resulted in a considerable loss of inhibitive activity in the tobacco hornworm or the yellowfever mosquito. However, certain modifications of the azasteroid nucleus resulted in compounds that still retained high biological activity. As a result, a compound was synthesized that lacked the A and B rings of the steroid nucleus and that inhibited insect growth, molting, and metamorphosis and the Δ24-sterol reductase enzyme system of the tobacco hornworm. © 1975 American Oil Chemists' Society.
Scientific Publication
You may also be interested in