Lipids
Thompson, M.J., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Serban, N.N., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Robbins, W.E., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Svoboda, J.A., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Shortino, T.J., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Dutky, S.R., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Cohen, C.F., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
A number of azasteroids and other nitrogen containing steroids with a modified nucleus or side chain were prepared and tested for their inhibitory effects on the growth and development of several species of insects. Structure-activity studies showed that compounds with a structurally related steroid nucleus and side chain were approximately equal in inhibitory activity for a particular species. The replacement of the tertiary amino group in the side chain of the 5β-steroid with other nitrogen substituents, such as nitro, cyano, acetylamino, or a quaternary ammonium salt, resulted in a considerable loss of inhibitive activity in the tobacco hornworm or the yellowfever mosquito. However, certain modifications of the azasteroid nucleus resulted in compounds that still retained high biological activity. As a result, a compound was synthesized that lacked the A and B rings of the steroid nucleus and that inhibited insect growth, molting, and metamorphosis and the Δ24-sterol reductase enzyme system of the tobacco hornworm. © 1975 American Oil Chemists' Society.
פותח על ידי קלירמאש פתרונות בע"מ -
הספר "אוצר וולקני"
אודות
תנאי שימוש
Inhibitive effects of structurally modified azasteroids and related nitrogen containing steroids on insect growth and development
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Thompson, M.J., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Serban, N.N., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Robbins, W.E., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Svoboda, J.A., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Shortino, T.J., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Dutky, S.R., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Cohen, C.F., Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, Beltsville, 20705, Maryland, United States
Inhibitive effects of structurally modified azasteroids and related nitrogen containing steroids on insect growth and development
A number of azasteroids and other nitrogen containing steroids with a modified nucleus or side chain were prepared and tested for their inhibitory effects on the growth and development of several species of insects. Structure-activity studies showed that compounds with a structurally related steroid nucleus and side chain were approximately equal in inhibitory activity for a particular species. The replacement of the tertiary amino group in the side chain of the 5β-steroid with other nitrogen substituents, such as nitro, cyano, acetylamino, or a quaternary ammonium salt, resulted in a considerable loss of inhibitive activity in the tobacco hornworm or the yellowfever mosquito. However, certain modifications of the azasteroid nucleus resulted in compounds that still retained high biological activity. As a result, a compound was synthesized that lacked the A and B rings of the steroid nucleus and that inhibited insect growth, molting, and metamorphosis and the Δ24-sterol reductase enzyme system of the tobacco hornworm. © 1975 American Oil Chemists' Society.
Scientific Publication