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פותח על ידי קלירמאש פתרונות בע"מ -
Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: The stomach as a bioreactor
Year:
2012
Authors :
קנר, יוסף
;
.
Volume :
60
Co-Authors:
Kanner, J., Department of Food Science, ARO, Volcani Center, Bet Dagan, Israel
Gorelik, S., Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Roman, S., Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Kohen, R., Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Facilitators :
From page:
8790
To page:
8796
(
Total pages:
7
)
Abstract:
Recent studies dramatically showed that the removal of circulating modified low-density lipoprotein (LDL) results in complete prevention of atherosclerosis. The gastrointestinal tract is constantly exposed to food, some of it containing oxidized compounds. Lipid oxidation in the stomach was demonstrated by ingesting heated red meat in rats. Red wine polyphenols added to the rats' meat diet prevented lipid peroxidation in the stomach and absorption of malondialdehyde (MDA) in rat plasma. In humans, postprandial plasma MDA levels rose by 3-fold after a meal of red meat cutlets. MDA derived from meat consumption caused postprandial plasma LDL modification in human. The levels of plasma MDA showed a 75% reduction by consumption of red wine polyphenols during the meat meal. Locating the main biological site of action of polyphenols in the stomach led to a revision in the understanding of how antioxidants work in vivo and may help to elucidate the mechanism involved in the protective effects of polyphenols in human health. © 2012 American Chemical Society.
Note:
Related Files :
Animal
Animals
antioxidants
Blood
Conference paper
drug effect
Lipoproteins, LDL
metabolism
oxidation
phenols
עוד תגיות
תוכן קשור
More details
DOI :
10.1021/jf300193g
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר מתוך כינוס
;
.
Language:
אנגלית
Editors' remarks:
ID:
32697
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:11
Scientific Publication
Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: The stomach as a bioreactor
60
Kanner, J., Department of Food Science, ARO, Volcani Center, Bet Dagan, Israel
Gorelik, S., Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Roman, S., Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Kohen, R., Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: The stomach as a bioreactor
Recent studies dramatically showed that the removal of circulating modified low-density lipoprotein (LDL) results in complete prevention of atherosclerosis. The gastrointestinal tract is constantly exposed to food, some of it containing oxidized compounds. Lipid oxidation in the stomach was demonstrated by ingesting heated red meat in rats. Red wine polyphenols added to the rats' meat diet prevented lipid peroxidation in the stomach and absorption of malondialdehyde (MDA) in rat plasma. In humans, postprandial plasma MDA levels rose by 3-fold after a meal of red meat cutlets. MDA derived from meat consumption caused postprandial plasma LDL modification in human. The levels of plasma MDA showed a 75% reduction by consumption of red wine polyphenols during the meat meal. Locating the main biological site of action of polyphenols in the stomach led to a revision in the understanding of how antioxidants work in vivo and may help to elucidate the mechanism involved in the protective effects of polyphenols in human health. © 2012 American Chemical Society.
Scientific Publication
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