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קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1)
Year:
1998
Source of publication :
Leukemia Research
Authors :
מושל, יאנה
;
.
Volume :
22
Co-Authors:
Morecki, S., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Nagler, A., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Zakay-Rones, Z., Department of Virology, Hebrew Univ. Hadassah Med. School, Jerusalem 91120, Israel
Schlesinger, M., Department of Virology, Hebrew Univ. Hadassah Med. School, Jerusalem 91120, Israel
Lubina-Salomon, A., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Pugatsch, T., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Moshel, Y., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Slavin, S., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Facilitators :
From page:
831
To page:
835
(
Total pages:
5
)
Abstract:
Multiple injections of intact irradiated BCL1 cells, a murine B-cell leukemia/lymphoma can trigger a dose-dependent anti-tumor immune response in naive syngeneic mice. The ability to induce anti-BCL1 immunity and the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection or transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given as a non-immunogenic cell-dose. New ways will have to be developed to elicit a reliable and reproducible anti-tumor effect in spontaneously arising and non-immunogenic hematological malignancies.
Note:
Related Files :
animal cell
animal experiment
animal model
Animals
gene transfer
Leukemia, B-Cell
mice
Transduction, Genetic
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/S0145-2126(98)00080-0
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
32749
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:12
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Scientific Publication
Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1)
22
Morecki, S., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Nagler, A., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Zakay-Rones, Z., Department of Virology, Hebrew Univ. Hadassah Med. School, Jerusalem 91120, Israel
Schlesinger, M., Department of Virology, Hebrew Univ. Hadassah Med. School, Jerusalem 91120, Israel
Lubina-Salomon, A., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Pugatsch, T., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Moshel, Y., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Slavin, S., Dept. of Bone Marrow Transplantation, Cancer Immunobiol. Res. Laboratory, Hadassah University Hospital, Jerusalem 91120, Israel
Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1)
Multiple injections of intact irradiated BCL1 cells, a murine B-cell leukemia/lymphoma can trigger a dose-dependent anti-tumor immune response in naive syngeneic mice. The ability to induce anti-BCL1 immunity and the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection or transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given as a non-immunogenic cell-dose. New ways will have to be developed to elicit a reliable and reproducible anti-tumor effect in spontaneously arising and non-immunogenic hematological malignancies.
Scientific Publication
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