אסיף מאגר המחקר החקלאי

The correlation between the synthesis of skeletal muscle actin, myosin heavy chain, and myosin light chain and the accumulation of corresponding mRNA sequences during myogenesis

Year:

1981

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Authors :

Volume :

86

Co-Authors:

Shani, M., Department of Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
Zevin-Sonkin, D., Department of Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
Saxel, O., Department of Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
Carmon, Y., Department of Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
Katcoff, D., Department of Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
Nudel, U., Department of Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
Yaffe, D., Department of Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel

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Abstract:

Cloned cDNA probes were used to measure the accumulation of myosin heavy chain, myosin light chain 2, and actin mRNA during differentiation of rat skeletal muscle cell cultures. This was compared with the changes in the rate of synthesis of the corresponding proteins. Accumulation of those mRNA sequences was detectable a few hours before the onset of the phase of cell fusion; however, the main increase in hybridizable RNA occurred during the phase of rapid cell fusion. A close correlation was found between the amounts of mRNAs coding for these proteins and the rate of synthesis of the proteins. The results suggest that the activation of stored mRNA is not a major mechanism for controlling the time at which these proteins are synthesized. © 1981.

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