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פותח על ידי קלירמאש פתרונות בע"מ -
Reduction of blood and liver cholesterol in the rat by straight and branched chain alkyl amines
Year:
1977
Source of publication :
Lipids
Authors :
סבובודה, ג'יימס
;
.
Volume :
12
Co-Authors:
Svoboda, J.A., Insect Physiology Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Wrenn, T.R., Nutrient Utilization Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Thompson, M.J., Insect Physiology Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Weyant, J.R., Nutrient Utilization Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Wood, D.L., Nutrient Utilization Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Bitman, J., Nutrient Utilization Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Facilitators :
From page:
691
To page:
697
(
Total pages:
7
)
Abstract:
The activities of a branched chain and several straight chain amines (C12 to C18 chain length), and the azasteroid 25-aza-5α-cholestane were compared with those of 20,25-diazacholesterol dihydrochloride, which is a potent hypocholesterolemic agent in the rat. These amines and azasteroids inhibit the Δ24-sterol reductase system in the tobacco hornworm, Manduca sexta (L.), and also block the conversion of C28 and C29 plant sterols to cholesterol, with a resulting accumulation of desmosterol. The effects of these compounds in the rat were determined on body weight gain, cholesterol, desmosterol, and lipid composition of blood, feces, liver, and epididymal fat pad weight. The two azasteroids and the branched chain amine, N,N-dimethyl-3, 7,11-trimethyldodecanamine, had the greatest effect, reducing total plasma lipids and plasma sterols to approximately 40-50% of the levels in control rats and produced a concomitant increase in plasma and liver desmosterol. The branched chain dodecanamine caused a reduction in both feed consumption and body weight gain. The branched and straight chain dodecanamines also severely reduced epididymal fat pad weight. Our results demonstrate that the simple azasteroid, 25-aza-5α-cholestane, is a more potent inhibitor of cholesterol biosynthesis than the diazasterol and that the Δ24-sterol reductase system in a mammal can be inhibited by simple, nonsteroidal, acyclic amines. © 1977 The American Oil Chemists' Society.
Note:
Related Files :
25 aza 5alpha cholestane
Animals
cholesterol blood level
fatty acids
Lipids
n,n dimethyltetradecylamine
Oxidoreductases
unclassified drug
עוד תגיות
תוכן קשור
More details
DOI :
10.1007/BF02570897
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
32774
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:12
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Scientific Publication
Reduction of blood and liver cholesterol in the rat by straight and branched chain alkyl amines
12
Svoboda, J.A., Insect Physiology Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Wrenn, T.R., Nutrient Utilization Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Thompson, M.J., Insect Physiology Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Weyant, J.R., Nutrient Utilization Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Wood, D.L., Nutrient Utilization Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Bitman, J., Nutrient Utilization Laboratory, ARS, USDA, Beltsville, 20705, MD, United States
Reduction of blood and liver cholesterol in the rat by straight and branched chain alkyl amines
The activities of a branched chain and several straight chain amines (C12 to C18 chain length), and the azasteroid 25-aza-5α-cholestane were compared with those of 20,25-diazacholesterol dihydrochloride, which is a potent hypocholesterolemic agent in the rat. These amines and azasteroids inhibit the Δ24-sterol reductase system in the tobacco hornworm, Manduca sexta (L.), and also block the conversion of C28 and C29 plant sterols to cholesterol, with a resulting accumulation of desmosterol. The effects of these compounds in the rat were determined on body weight gain, cholesterol, desmosterol, and lipid composition of blood, feces, liver, and epididymal fat pad weight. The two azasteroids and the branched chain amine, N,N-dimethyl-3, 7,11-trimethyldodecanamine, had the greatest effect, reducing total plasma lipids and plasma sterols to approximately 40-50% of the levels in control rats and produced a concomitant increase in plasma and liver desmosterol. The branched chain dodecanamine caused a reduction in both feed consumption and body weight gain. The branched and straight chain dodecanamines also severely reduced epididymal fat pad weight. Our results demonstrate that the simple azasteroid, 25-aza-5α-cholestane, is a more potent inhibitor of cholesterol biosynthesis than the diazasterol and that the Δ24-sterol reductase system in a mammal can be inhibited by simple, nonsteroidal, acyclic amines. © 1977 The American Oil Chemists' Society.
Scientific Publication
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