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פותח על ידי קלירמאש פתרונות בע"מ -
Inhibition of enkephalin-degrading enzymes from rat brain and of thermolysin by amino acid hydroxamates
Year:
1981
Source of publication :
Life Sciences
Authors :
אלטשטיין, מרים
;
.
Volume :
28
Co-Authors:
Blumberg, S., Departments of Biophysics and Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
Vogel, Z., Departments of Biophysics and Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
Altstein, M., Departments of Biophysics and Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
Facilitators :
From page:
301
To page:
306
(
Total pages:
6
)
Abstract:
Benzyloxycarbonyl derivatives (Z) of amino acid hydroxamates have been found to inhibit the bacterial metalloendopeptidase thermolysin and enkephalin-degrading enzymes from rat brain. The hydroxamate derivatives of glycine, leucine, phenylalanine and D-phenylalanine inhibit thermolysin with KI values in the range of 3-23 μM. They also inhibit the enkephalin-degrading endopeptidase (enkephalinase) and aminopeptidase with different efficiencies, depending on the structure of the amino acid employed. Thus, Z-Gly-NHOH inhibits the enkephalinase and aminopeptidase with IC50 values of 1 μM and 300 μM, respectively, whereas Z-D-Phe-NHOH inhibits the corresponding enzymes with IC50 values of 0.2 μM and 1.5 μM. © 1981.
Note:
Related Files :
amino acid derivative
Amino Acids
Animal
animal experiment
benzyloxycarbonyl n hydroxyaminoacid
Male
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/0024-3205(81)90737-2
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
32823
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:12
Scientific Publication
Inhibition of enkephalin-degrading enzymes from rat brain and of thermolysin by amino acid hydroxamates
28
Blumberg, S., Departments of Biophysics and Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
Vogel, Z., Departments of Biophysics and Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
Altstein, M., Departments of Biophysics and Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
Inhibition of enkephalin-degrading enzymes from rat brain and of thermolysin by amino acid hydroxamates
Benzyloxycarbonyl derivatives (Z) of amino acid hydroxamates have been found to inhibit the bacterial metalloendopeptidase thermolysin and enkephalin-degrading enzymes from rat brain. The hydroxamate derivatives of glycine, leucine, phenylalanine and D-phenylalanine inhibit thermolysin with KI values in the range of 3-23 μM. They also inhibit the enkephalin-degrading endopeptidase (enkephalinase) and aminopeptidase with different efficiencies, depending on the structure of the amino acid employed. Thus, Z-Gly-NHOH inhibits the enkephalinase and aminopeptidase with IC50 values of 1 μM and 300 μM, respectively, whereas Z-D-Phe-NHOH inhibits the corresponding enzymes with IC50 values of 0.2 μM and 1.5 μM. © 1981.
Scientific Publication
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