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פותח על ידי קלירמאש פתרונות בע"מ -
The effect of ambient ph modulation on ochratoxin a accumulation by aspergillus carbonarius
Year:
2017
Source of publication :
World Mycotoxin Journal
Authors :
זקין, ורדה
;
.
מאור, א'
;
.
סדאסיוואן, סודרסאן
;
.
סיונוב, אדוארד
;
.
פרוסקי, דב
;
.
Volume :
10
Co-Authors:
Facilitators :
From page:
339
To page:
348
(
Total pages:
10
)
Abstract:

Aspergillus carbonarius, the main cause of severe post-harvest decay of vine fruit, is considered the major source of ochratoxin A (OTA) contamination of grapes and derived products. The factors inducing OTA accumulation by A. carbonarius and its contribution to pathogenicity remain unclear. Present findings indicate that the production of organic acids, such as D-gluconic acid (GLA) and citric acid, by A. carbonarius in the growth medium or in the decayed fruit tissue was directly related to ambient pH reduction. Under these conditions, induced transcript expression of genes involved in OTA biosynthesis occurred concurrently with mycotoxin accumulation. The high accumulation of OTA during acidification process raised the question of its importance in host-pathogen interactions during the fungal colonisation. Treatment of colonised grapes with sodium bicarbonate reduced accumulation of organic acid and OTA with a concomitant reduction in decay development, suggesting that tissue acidification is a significant factor in A. carbonarius pathogenicity. The present findings suggest that ambient pH is a regulatory signal for induction of mycotoxin production by A. carbonarius under the dynamic nutritional growth conditions occurring in culture. Yet the molecular mechanisms of OTA biosynthesis induction during colonisation of the acidic host environment are still unclear and should be further investigated. © 2017 Wageningen Academic Publishers.

Note:
Related Files :
biosynthesis
gene expression
gluconic acid
host pathogen interaction
Organic acids
pH measurement
sucrose
עוד תגיות
תוכן קשור
More details
DOI :
https://doi.org/10.3920/WMJ2017.2200
Article number:
0
Affiliations:

Department of Food Quality and Safety, Institute for Postharvest and Food Sciences, Agricultural Research Organization, Bet Dagan, Israel; Institute of Biochemistry, Robert H. Smith Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel

Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
36531
Last updated date:
02/03/2022 17:27
Creation date:
08/08/2018 15:52
Scientific Publication
The effect of ambient ph modulation on ochratoxin a accumulation by aspergillus carbonarius
10
The effect of ambient ph modulation on ochratoxin a accumulation by aspergillus carbonarius

Aspergillus carbonarius, the main cause of severe post-harvest decay of vine fruit, is considered the major source of ochratoxin A (OTA) contamination of grapes and derived products. The factors inducing OTA accumulation by A. carbonarius and its contribution to pathogenicity remain unclear. Present findings indicate that the production of organic acids, such as D-gluconic acid (GLA) and citric acid, by A. carbonarius in the growth medium or in the decayed fruit tissue was directly related to ambient pH reduction. Under these conditions, induced transcript expression of genes involved in OTA biosynthesis occurred concurrently with mycotoxin accumulation. The high accumulation of OTA during acidification process raised the question of its importance in host-pathogen interactions during the fungal colonisation. Treatment of colonised grapes with sodium bicarbonate reduced accumulation of organic acid and OTA with a concomitant reduction in decay development, suggesting that tissue acidification is a significant factor in A. carbonarius pathogenicity. The present findings suggest that ambient pH is a regulatory signal for induction of mycotoxin production by A. carbonarius under the dynamic nutritional growth conditions occurring in culture. Yet the molecular mechanisms of OTA biosynthesis induction during colonisation of the acidic host environment are still unclear and should be further investigated. © 2017 Wageningen Academic Publishers.

Scientific Publication
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