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אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Structure-function analysis of PBAN/MRCH: a basis for antagonist design
Year:
1997
Authors :
אלטשטיין, מרים
;
.
בן-עזיז, אורנה
;
.
גבאי, טל
;
.
גזית, יואב
;
.
דונקלבלום, עזרא
;
.
Volume :
Co-Authors:
  • Zvi Vogel
  • Jacob Barg
Facilitators :
From page:
111
To page:
118
(
Total pages:
8
)
Abstract:

Insect neuropeptides play a key role in the regulation of a variety of physiological functions such as embryonic and post-embryonic development, homeostasis, osmoregulation, migration, oviposition and mating (for review, see Menn and Borkovec, 1989; Kelly et al., 1994). In recent years, improvements of biochemical and chemical techniques have facilitated the chemical identification of insect neuropeptides, and over 80 insect neuropeptides have been isolated and sequenced to date (for review, see Kelly et al., 1994). The varied functional capacities of this group of regulatory substances provide new strategies for insect control. Control could be based on interference with the basic processes associated with neuropeptide activity: biosynthesis, release, transport, binding and degradation. Among these processes, the most effective and susceptible to manipulation is the binding to the target receptors. Blocking of the binding may be achieved by selective antagonists, which prevent receptor activation by the neuropeptide. To design potent antagonists, the structure-activity relationship of the neuropeptide must be revealed and the active as well as inactive sequences in the molecule have to be identified. We have used this approach to study the structure-function relationship of an insect neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN; Raina and Klun, 1984; Raina et al., 1989), also known as melanization and reddish coloration hormone (MRCH; Matsumoto et al., 1981, 1990), which regulates two functions in moths: sex pheromone biosynthesis and cuticular melanization (for review, see Raina, 1993).

Note:

Part of the Developments in Plant and Soil Sciences book series (DPSS, volume 71)

Related Files :
Cuticular Melanisation
insects
Neuropeptides
PBAN antagonists
Pheromone biosynthesis
pheromones
plant protection
sex pheromones
עוד תגיות
תוכן קשור
More details
DOI :
https://doi.org/10.1007/978-94-011-5418-5_9
Article number:
0
Affiliations:
Database:
גוגל סקולר
Publication Type:
מאמר מתוך כינוס
;
.
פרק מתוך ספר
;
.
Language:
אנגלית
Editors' remarks:
ID:
37739
Last updated date:
02/03/2022 17:27
Creation date:
29/10/2018 11:33
Scientific Publication
Structure-function analysis of PBAN/MRCH: a basis for antagonist design
  • Zvi Vogel
  • Jacob Barg
Structure-function analysis of PBAN/MRCH: a basis for antagonist design

Insect neuropeptides play a key role in the regulation of a variety of physiological functions such as embryonic and post-embryonic development, homeostasis, osmoregulation, migration, oviposition and mating (for review, see Menn and Borkovec, 1989; Kelly et al., 1994). In recent years, improvements of biochemical and chemical techniques have facilitated the chemical identification of insect neuropeptides, and over 80 insect neuropeptides have been isolated and sequenced to date (for review, see Kelly et al., 1994). The varied functional capacities of this group of regulatory substances provide new strategies for insect control. Control could be based on interference with the basic processes associated with neuropeptide activity: biosynthesis, release, transport, binding and degradation. Among these processes, the most effective and susceptible to manipulation is the binding to the target receptors. Blocking of the binding may be achieved by selective antagonists, which prevent receptor activation by the neuropeptide. To design potent antagonists, the structure-activity relationship of the neuropeptide must be revealed and the active as well as inactive sequences in the molecule have to be identified. We have used this approach to study the structure-function relationship of an insect neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN; Raina and Klun, 1984; Raina et al., 1989), also known as melanization and reddish coloration hormone (MRCH; Matsumoto et al., 1981, 1990), which regulates two functions in moths: sex pheromone biosynthesis and cuticular melanization (for review, see Raina, 1993).

Part of the Developments in Plant and Soil Sciences book series (DPSS, volume 71)

Scientific Publication
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