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Galaktionova, D., Department of Chemistry, University of Illinois at Chicago, Chicago, IL  60607, United States; Golden, G., Postharvest and Food Science Institute, Agricultural Research Organization, Volcani Center, Rishon LeZion, 50250, Israel; Cohen, Y., Postharvest and Food Science Institute, Agricultural Research Organization, Volcani Center, Rishon LeZion, 50250, Israel, Environmental Studies and Agricultural Resources, Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Rehovot, 76100, Israel; Levi-Kalisman, Y., Center for Nanoscience and Nanotechnology, Silberman Institute for Life Sciences, Hebrew University of Jerusalem, Jerusalem, 91904, Israel; Cohen, G., Skin Research Institute, Dead Sea and Arava Science Center, Masada, 86910, Israel; Král, P., Department of Chemistry, University of Illinois at Chicago, Chicago, IL  60607, United States, Departments of Physics and Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL  60607, United States; Poverenov, E., Postharvest and Food Science Institute, Agricultural Research Organization, Volcani Center, Rishon LeZion, 50250, Israel

Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics. © 2018 American Chemical Society.

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הספר "אוצר וולקני"
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תנאי שימוש
Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems
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Galaktionova, D., Department of Chemistry, University of Illinois at Chicago, Chicago, IL  60607, United States; Golden, G., Postharvest and Food Science Institute, Agricultural Research Organization, Volcani Center, Rishon LeZion, 50250, Israel; Cohen, Y., Postharvest and Food Science Institute, Agricultural Research Organization, Volcani Center, Rishon LeZion, 50250, Israel, Environmental Studies and Agricultural Resources, Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Rehovot, 76100, Israel; Levi-Kalisman, Y., Center for Nanoscience and Nanotechnology, Silberman Institute for Life Sciences, Hebrew University of Jerusalem, Jerusalem, 91904, Israel; Cohen, G., Skin Research Institute, Dead Sea and Arava Science Center, Masada, 86910, Israel; Král, P., Department of Chemistry, University of Illinois at Chicago, Chicago, IL  60607, United States, Departments of Physics and Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL  60607, United States; Poverenov, E., Postharvest and Food Science Institute, Agricultural Research Organization, Volcani Center, Rishon LeZion, 50250, Israel

Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems

Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics. © 2018 American Chemical Society.

Scientific Publication
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