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פותח על ידי קלירמאש פתרונות בע"מ -
Glutathione/pH-responsive nanosponges enhance strigolactone delivery to prostate cancer cells
Year:
2018
Source of publication :
Oncotarget
Authors :
קולטאי, חננית
;
.
קפולניק, יורם
;
.
Volume :
9
Co-Authors:

Argenziano, M., Department of Drug Science and Technology, University of Turin, Turin, Italy; Lombardi, C., Department of Chemistry, University of Turin, Turin, Italy; Ferrara, B., Department of Drug Science and Technology, University of Turin, Turin, Italy; Trotta, F., Department of Chemistry, University of Turin, Turin, Italy; Caldera, F., Department of Chemistry, University of Turin, Turin, Italy; Blangetti, M., Department of Chemistry, University of Turin, Turin, Italy; Yarden, R., Georgetown University Medical Center, Washington, DC, United States; Gigliotti, L., Department of Health Sciences, Universita del Piemonte Orientale, Novara, Italy; Dianzani, U., Department of Health Sciences, Universita del Piemonte Orientale, Novara, Italy; Dianzani, C., Department of Drug Science and Technology, University of Turin, Turin, Italy; Prandi, C., Department of Chemistry, University of Turin, Turin, Italy; Cavalli, R., Department of Drug Science and Technology, University of Turin, Turin, Italy

Facilitators :
From page:
35813
To page:
35829
(
Total pages:
17
)
Abstract:

Strigolactones (SLs) are carotenoid-derived plant hormones that exhibit anticancer activities. We previously demonstrated that two SL analogues, MEB55 and ST362, inhibit the growth and survival of various cancer cell lines. However, these compounds have low aqueous solubility and stability at physiological pH. Here, we generated SL-loaded glutathione/pH-responsive nanosponges (GSH/pH-NS) to selectively deliver SLs to prostate cancer cells and enhance their therapeutic efficacy. The SLs were readily incorporated into the GSH/pH-NS. The drug loading efficiency was 13.9% for MEB55 and 15.4% for ST362, and the encapsulation efficiency was 88.7% and 96.5%, respectively. Kinetic analysis revealed that release of MEB55 and ST362 from the GSH/pH-NS was accelerated at acidic pH and in the presence of a high GSH concentration. Evaluation of the effects of MEB55- and ST362-loaded GSH/pH-NS on the growth of DU145 (high GSH) and PC-3 (low GSH) prostate cancer cells revealed that the GSH/pH-NS inhibited the proliferation of DU145 cells to a greater extent than free MEB55 or ST362 over a range of concentrations. These findings indicate GSH/ pH-NS are efficient tools for controlled delivery of SLs to prostate cancer cells and may enhance the therapeutic efficacy of these compounds. © Copyright: Argenziano et al.

Note:
Related Files :
Controlled release
GSH/pH-responsive nanosponges
Intracellular delivery
prostate cancer cell line
Strigolactones
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
38143
Last updated date:
02/03/2022 17:27
Creation date:
27/11/2018 09:25
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Scientific Publication
Glutathione/pH-responsive nanosponges enhance strigolactone delivery to prostate cancer cells
9

Argenziano, M., Department of Drug Science and Technology, University of Turin, Turin, Italy; Lombardi, C., Department of Chemistry, University of Turin, Turin, Italy; Ferrara, B., Department of Drug Science and Technology, University of Turin, Turin, Italy; Trotta, F., Department of Chemistry, University of Turin, Turin, Italy; Caldera, F., Department of Chemistry, University of Turin, Turin, Italy; Blangetti, M., Department of Chemistry, University of Turin, Turin, Italy; Yarden, R., Georgetown University Medical Center, Washington, DC, United States; Gigliotti, L., Department of Health Sciences, Universita del Piemonte Orientale, Novara, Italy; Dianzani, U., Department of Health Sciences, Universita del Piemonte Orientale, Novara, Italy; Dianzani, C., Department of Drug Science and Technology, University of Turin, Turin, Italy; Prandi, C., Department of Chemistry, University of Turin, Turin, Italy; Cavalli, R., Department of Drug Science and Technology, University of Turin, Turin, Italy

Glutathione/pH-responsive nanosponges enhance strigolactone delivery to prostate cancer cells

Strigolactones (SLs) are carotenoid-derived plant hormones that exhibit anticancer activities. We previously demonstrated that two SL analogues, MEB55 and ST362, inhibit the growth and survival of various cancer cell lines. However, these compounds have low aqueous solubility and stability at physiological pH. Here, we generated SL-loaded glutathione/pH-responsive nanosponges (GSH/pH-NS) to selectively deliver SLs to prostate cancer cells and enhance their therapeutic efficacy. The SLs were readily incorporated into the GSH/pH-NS. The drug loading efficiency was 13.9% for MEB55 and 15.4% for ST362, and the encapsulation efficiency was 88.7% and 96.5%, respectively. Kinetic analysis revealed that release of MEB55 and ST362 from the GSH/pH-NS was accelerated at acidic pH and in the presence of a high GSH concentration. Evaluation of the effects of MEB55- and ST362-loaded GSH/pH-NS on the growth of DU145 (high GSH) and PC-3 (low GSH) prostate cancer cells revealed that the GSH/pH-NS inhibited the proliferation of DU145 cells to a greater extent than free MEB55 or ST362 over a range of concentrations. These findings indicate GSH/ pH-NS are efficient tools for controlled delivery of SLs to prostate cancer cells and may enhance the therapeutic efficacy of these compounds. © Copyright: Argenziano et al.

Scientific Publication
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