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פותח על ידי קלירמאש פתרונות בע"מ -
Biologically Active Compounds from the Israeli Flora Affecting the Cytoskeleton Organization of Cancer Cells [abstract]
Year:
2010
Authors :
אבו-עביד, מוחמד
;
.
דודאי, נתיב
;
.
הלפרט, מיכל
;
.
יהודה, אסנת
;
.
מוסקוביץ', יוני
;
.
פרל, אבי
;
.
שדות, עינת
;
.
Volume :
46 (supplement)
Co-Authors:

Riov, Joseph - Department of Horticulture, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Natural products have been a source for many approved drugs and serve as scaffolds for combinatorial library design. The Israeli flora is rich in ethno-botanical characterized medicinal plants with traditional uses. There are more than 2,600 native species in Israel, of which more than 700 are noted for their uses as medicinal herbs or biological pesticides. In an ongoing study, 1,500 samples were collected, identified, ground, and freeze-dried. Methanol extracts of the samples were applied to different cancer cell lines, which were then fixed and stained for actin, microtubules, or b-catenin. A new biological activity was found in extract #406, which led to increased cancerous cell adhesion and actin stress fibers formation in a Rac1- dependent manner. As a result, decreased cell migration and proliferation occurred. Extract #762 was found to be able to exclude b-catenin from the nucleus of SW480 colon cancer cells. In the colon cancer cell line SW480, the oncogene b-catenin accumulates in the nucleus, where it activates other oncogenes. This accumulation of b-catenin results from a mutation in APC, a mutation that characterizes about 85% of the cases of colon cancer and can happen dozens of years before the onset of the disease. A drug that will prevent b-catenin from accumulation in the nucleus in colon cells could potentially serve as a prophylactic treatment. In addition, extract #1503 exhibits vinblastine-like activity, which disrupts microtubules. Disruption of microtubules leads to cell cycle arrest and apoptosis. Work to identify the active compounds is in progress.

Note:

P. S49

Related Files :
Active compounds
cancer (disease)
cytoskeleton
Israel
medicinal plants
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
0
Affiliations:
Database:
גוגל סקולר
Publication Type:
מאמר מתוך כינוס
;
.
תקציר
;
.
Language:
אנגלית
Editors' remarks:
ID:
38618
Last updated date:
02/03/2022 17:27
Creation date:
18/12/2018 08:00
Scientific Publication
Biologically Active Compounds from the Israeli Flora Affecting the Cytoskeleton Organization of Cancer Cells [abstract]
46 (supplement)

Riov, Joseph - Department of Horticulture, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel

Natural products have been a source for many approved drugs and serve as scaffolds for combinatorial library design. The Israeli flora is rich in ethno-botanical characterized medicinal plants with traditional uses. There are more than 2,600 native species in Israel, of which more than 700 are noted for their uses as medicinal herbs or biological pesticides. In an ongoing study, 1,500 samples were collected, identified, ground, and freeze-dried. Methanol extracts of the samples were applied to different cancer cell lines, which were then fixed and stained for actin, microtubules, or b-catenin. A new biological activity was found in extract #406, which led to increased cancerous cell adhesion and actin stress fibers formation in a Rac1- dependent manner. As a result, decreased cell migration and proliferation occurred. Extract #762 was found to be able to exclude b-catenin from the nucleus of SW480 colon cancer cells. In the colon cancer cell line SW480, the oncogene b-catenin accumulates in the nucleus, where it activates other oncogenes. This accumulation of b-catenin results from a mutation in APC, a mutation that characterizes about 85% of the cases of colon cancer and can happen dozens of years before the onset of the disease. A drug that will prevent b-catenin from accumulation in the nucleus in colon cells could potentially serve as a prophylactic treatment. In addition, extract #1503 exhibits vinblastine-like activity, which disrupts microtubules. Disruption of microtubules leads to cell cycle arrest and apoptosis. Work to identify the active compounds is in progress.

P. S49

Scientific Publication
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