נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Biosynthesis of amphetamine-like alkaloids in Catha edulis and Ephedra spp., two distantly related taxa [abstract]
Year:
2015
Authors :
בר, עינת
;
.
דודאי, נתיב
;
.
לוי, אסף
;
.
לוינסון, אפרים
;
.
קריזבסקי, רז
;
.
Volume :
Co-Authors:

J. Hagel, R.A. Groves, K. Kilpatrick, Y. Zhang, C.W. Sensen, S. Ben Shabat, S. Yaron, M. Frederic, P.J. Facchini

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Ephedrine alkaloids such as (1S)(2S)-norpseudoephedrine, (1S)(2S)-pseudoephedrine, (1R)(2S)-norephedrine and (1R)(2S)-ephedrine are commercially important amphetamine-like alkaloids present in plants of taxonomically distant families. Ephedra sinica (Ephedraceae) is a gymnosperm widely used in Chinese medicine. Catha edulis (Celastraceae), known by it's common name "khat" is an angiosperm whose leaves are traditionally chewed as a stimulant in the Middle East and Eastern Africa. Very little is known about the mechanisms by which such plants biosynthesize these compounds. We established a comparative functional genomics platform to facilitate the study of the biochemical and molecular mechanisms that direct the accumulation of ephedrine alkaloids. Targeted metabolomic analyses coupled with biochemical and molecular studies have demonstrated that both plants apparently utilize similar biosynthetic pathways for the ephedrine alkaloid biosynthesis. Key enzymes and putative genes involved in ephedrine alkaloid biosynthesis have been identified. The multidisciplinary functional genomics and metabolomic platforms established will contribute to our understanding of the biosynthetic pathway, key enzymatic steps and the regulation of this little studied biosynthetic pathway. Acknowledgements: This work was supported by the Israel Science Foundation (Grant No. 814/06) and a grant (CA-9117-09) from the Canada-Israel Binational Agricultural Research and Development Fund.

Note:

Spring 2015, including AGFD abstracts for the 249th American Chemical Society National Meeting March 22-26, 2015

Related Files :
Alkaloids
biosynthesis
Catha edulis
Ephedra sinica
ephedrine
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
0
Affiliations:
Database:
גוגל סקולר
Publication Type:
מאמר מתוך כינוס
;
.
תקציר
;
.
Language:
אנגלית
Editors' remarks:
ID:
38619
Last updated date:
02/03/2022 17:27
Creation date:
18/12/2018 08:20
You may also be interested in
Scientific Publication
Biosynthesis of amphetamine-like alkaloids in Catha edulis and Ephedra spp., two distantly related taxa [abstract]

J. Hagel, R.A. Groves, K. Kilpatrick, Y. Zhang, C.W. Sensen, S. Ben Shabat, S. Yaron, M. Frederic, P.J. Facchini

Ephedrine alkaloids such as (1S)(2S)-norpseudoephedrine, (1S)(2S)-pseudoephedrine, (1R)(2S)-norephedrine and (1R)(2S)-ephedrine are commercially important amphetamine-like alkaloids present in plants of taxonomically distant families. Ephedra sinica (Ephedraceae) is a gymnosperm widely used in Chinese medicine. Catha edulis (Celastraceae), known by it's common name "khat" is an angiosperm whose leaves are traditionally chewed as a stimulant in the Middle East and Eastern Africa. Very little is known about the mechanisms by which such plants biosynthesize these compounds. We established a comparative functional genomics platform to facilitate the study of the biochemical and molecular mechanisms that direct the accumulation of ephedrine alkaloids. Targeted metabolomic analyses coupled with biochemical and molecular studies have demonstrated that both plants apparently utilize similar biosynthetic pathways for the ephedrine alkaloid biosynthesis. Key enzymes and putative genes involved in ephedrine alkaloid biosynthesis have been identified. The multidisciplinary functional genomics and metabolomic platforms established will contribute to our understanding of the biosynthetic pathway, key enzymatic steps and the regulation of this little studied biosynthetic pathway. Acknowledgements: This work was supported by the Israel Science Foundation (Grant No. 814/06) and a grant (CA-9117-09) from the Canada-Israel Binational Agricultural Research and Development Fund.

Spring 2015, including AGFD abstracts for the 249th American Chemical Society National Meeting March 22-26, 2015

Scientific Publication
You may also be interested in