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פותח על ידי קלירמאש פתרונות בע"מ -
Effects of sodium salicylate on glucose kinetics and insulin signaling in postpartum dairy cows
Year:
2018
Source of publication :
Journal of Dairy Science
Authors :
זכות, מאיה
;
.
קרא, גיתית
;
.
Volume :
102
Co-Authors:

Montgomery, S.R., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States; Mamedova, L.K., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States;  Häussler, S., Institute of Animal Science, Physiology and Hygiene Unit, University of BonnD-53012, Germany; Vaughn, M., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States; Gonzalez, J., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States; Bradford, B.J., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States

Facilitators :
From page:
1617
To page:
1629
(
Total pages:
13
)
Abstract:

Low-grade inflammation has been implicated as a contributor to metabolic disease during the transition to lactation. In previous work, administration of sodium salicylate (SS) for 7 d led to hypoglycemia in mature dairy cows in early lactation. The purpose of this study was to identify the mode of action underlying this response to SS. Twenty mature (parity 3) cows were assigned alternately at time of calving to either control or SS treatments; the control received a molasses placebo in drinking water, whereas SS received 2.3 g/L of SS with the molasses carrier in drinking water for 7 d after parturition. Blood samples were collected daily. A glucose turnover assay was performed on d 7, followed by liver, muscle, and adipose tissue biopsies. There were no treatment effects on intake of dry matter or water. Tumor necrosis factor α mRNA abundance tended to be decreased by SS in adipose tissue but not in muscle or liver, and plasma haptoglobin and adiponectin concentrations were not altered by treatment. Treatment did not significantly alter plasma glucose or insulin concentrations, but plasma glucagon concentration tended to be increased by SS and the insulin:glucagon molar ratio was significantly decreased. Cows on SS had a tendency for a 25% decrease in glucose turnover rate compared with control cows. However, there were no differences in transcript abundance of pyruvate carboxylase (PC) or glucose-6-phosphatase (G6PC) in liver or of glucose transporter 4 (GLUT4) in any of the tissues. Finally, SS did not alter insulin receptor substrate-1 phosphorylation in muscle or adipose, but tended to increase phosphorylation of AMP-activated protein kinase and decrease protein kinase B phosphorylation in adipose tissue. These findings may be explained by enhanced hepatic insulin sensitivity leading to posttranscriptional suppression of gluconeogenesis and adaptive responses to decreased glucose supply in the pancreas and adipose tissue. © 2019 American Dairy Science Association

Note:
Related Files :
Inflammation
insulin signaling
nonsteroidal anti-inflammatory drug
Transition cow
Transition cows
עוד תגיות
תוכן קשור
More details
DOI :
10.3168/jds.2018-15312
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
38940
Last updated date:
02/03/2022 17:27
Creation date:
09/01/2019 08:50
You may also be interested in
Scientific Publication
Effects of sodium salicylate on glucose kinetics and insulin signaling in postpartum dairy cows
102

Montgomery, S.R., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States; Mamedova, L.K., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States;  Häussler, S., Institute of Animal Science, Physiology and Hygiene Unit, University of BonnD-53012, Germany; Vaughn, M., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States; Gonzalez, J., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States; Bradford, B.J., Department of Animal Sciences and Industry, Kansas State University, Manhattan, 66506, United States

Effects of sodium salicylate on glucose kinetics and insulin signaling in postpartum dairy cows

Low-grade inflammation has been implicated as a contributor to metabolic disease during the transition to lactation. In previous work, administration of sodium salicylate (SS) for 7 d led to hypoglycemia in mature dairy cows in early lactation. The purpose of this study was to identify the mode of action underlying this response to SS. Twenty mature (parity 3) cows were assigned alternately at time of calving to either control or SS treatments; the control received a molasses placebo in drinking water, whereas SS received 2.3 g/L of SS with the molasses carrier in drinking water for 7 d after parturition. Blood samples were collected daily. A glucose turnover assay was performed on d 7, followed by liver, muscle, and adipose tissue biopsies. There were no treatment effects on intake of dry matter or water. Tumor necrosis factor α mRNA abundance tended to be decreased by SS in adipose tissue but not in muscle or liver, and plasma haptoglobin and adiponectin concentrations were not altered by treatment. Treatment did not significantly alter plasma glucose or insulin concentrations, but plasma glucagon concentration tended to be increased by SS and the insulin:glucagon molar ratio was significantly decreased. Cows on SS had a tendency for a 25% decrease in glucose turnover rate compared with control cows. However, there were no differences in transcript abundance of pyruvate carboxylase (PC) or glucose-6-phosphatase (G6PC) in liver or of glucose transporter 4 (GLUT4) in any of the tissues. Finally, SS did not alter insulin receptor substrate-1 phosphorylation in muscle or adipose, but tended to increase phosphorylation of AMP-activated protein kinase and decrease protein kinase B phosphorylation in adipose tissue. These findings may be explained by enhanced hepatic insulin sensitivity leading to posttranscriptional suppression of gluconeogenesis and adaptive responses to decreased glucose supply in the pancreas and adipose tissue. © 2019 American Dairy Science Association

Scientific Publication
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