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פותח על ידי קלירמאש פתרונות בע"מ -
Extract of Achillea fragrantissima Downregulates ROS Production and Protects Astrocytes from Oxidative-Stress-Induced Cell Death
Year:
2011
Source of publication :
https://www.intechopen.com/
Authors :
אלמן, ענת
;
.
ארלנק, הילה
;
.
טלרמן, אלונה
;
.
מרדכי, שרון
;
.
רינדנר, מרים
;
.
Volume :
Co-Authors:

Rivka Ofir - Dead Sea & Arava Science Center and Department of Microbiology & Immunology Ben-Gurion University of the Negev, Beer-Sheva, Israel 

Elie Beit-Yannai -Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer‑Sheva, Israel 

Facilitators :
From page:
435
To page:
452
(
Total pages:
18
)
Abstract:

Oxidative damage plays a pivotal role in the initiation and progress of many human diseases and also in the development of acute and chronic pathological conditions in brain tissue (Halliwell, 2006; Hyslop et al., 1995; Ischiropoulos & Beckman, 2003; Minghetti, 2005). Compared with other tissues, the brain is particularly vulnerable to oxidative damage due to its high rate of oxygen utilization and high contents of oxidizable polyunsaturated fatty acids (Floyd, 1999; Sastry, 1985). In addition, certain regions of the brain are highly enriched in iron, a metal that is catalytically involved in the production of damaging reactive oxygen species (ROS) (Hallgren & Sourander, 1958). Although ROS are critical intracellular signaling messengers  (Schrecka & Baeuerlea, 1991), excess of free radicals may lead to peroxidative impairment of membrane lipids and, consequently, to disruption of neuronal functions, and apoptosis. Among the ROS that are responsible for oxidative stress, H2O2 is thought to be the major precursor of highly reactive free radicals, and is regarded as a key factor in both neuronal (Vaudry et al., 2002) and astroglial cell death (Ferrero-Gutierrez et al., 2008). H2O2 is normally produced in reactions predominantly catalyzed by superoxide dismutase (SOD) and monoaminoxidases (MAO) A and B in the brain (Almeida et al., 2006; Duarte et al., 2007).......

Note:
Related Files :
Achillea fragrantissima
Astrocytes
cell death
Oxidative-stress
Oxidative damage
ROS
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
0
Affiliations:
Database:
גוגל סקולר
Publication Type:
פרק מתוך ספר
;
.
Language:
אנגלית
Editors' remarks:
ID:
39560
Last updated date:
02/03/2022 17:27
Creation date:
19/03/2019 11:01
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Scientific Publication
Extract of Achillea fragrantissima Downregulates ROS Production and Protects Astrocytes from Oxidative-Stress-Induced Cell Death

Rivka Ofir - Dead Sea & Arava Science Center and Department of Microbiology & Immunology Ben-Gurion University of the Negev, Beer-Sheva, Israel 

Elie Beit-Yannai -Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer‑Sheva, Israel 

Oxidative damage plays a pivotal role in the initiation and progress of many human diseases and also in the development of acute and chronic pathological conditions in brain tissue (Halliwell, 2006; Hyslop et al., 1995; Ischiropoulos & Beckman, 2003; Minghetti, 2005). Compared with other tissues, the brain is particularly vulnerable to oxidative damage due to its high rate of oxygen utilization and high contents of oxidizable polyunsaturated fatty acids (Floyd, 1999; Sastry, 1985). In addition, certain regions of the brain are highly enriched in iron, a metal that is catalytically involved in the production of damaging reactive oxygen species (ROS) (Hallgren & Sourander, 1958). Although ROS are critical intracellular signaling messengers  (Schrecka & Baeuerlea, 1991), excess of free radicals may lead to peroxidative impairment of membrane lipids and, consequently, to disruption of neuronal functions, and apoptosis. Among the ROS that are responsible for oxidative stress, H2O2 is thought to be the major precursor of highly reactive free radicals, and is regarded as a key factor in both neuronal (Vaudry et al., 2002) and astroglial cell death (Ferrero-Gutierrez et al., 2008). H2O2 is normally produced in reactions predominantly catalyzed by superoxide dismutase (SOD) and monoaminoxidases (MAO) A and B in the brain (Almeida et al., 2006; Duarte et al., 2007).......

Scientific Publication
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