Uppal, K., Department of Cardiology/Pulmonary Hypertension, University of Minnesota Clinics and Surgery Center, Minneaoplis, MN, United States; Gupta, M., Department of Biotechnology, School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, India

Ever since the landmark discovery of paclitaxel from endophytic Taxomyces andreanae, plant endophytes have been the fountainheads of bioactive secondary metabolites with potential application in medicine, agriculture, and food industry. In the last two decades, lead molecules with antimicrobial, anticancer, antioxidant, and anti-inflammatory properties have been successfully discovered from endophytic microorganisms. Bioprospecting endophytes for enzyme inhibitors has been an important facet of endophytic research. Several enzyme inhibitors like altenusin, huperzine, camptothecin, and podophyllotoxin have been successfully isolated from endophytic microorganisms. The current chapter partially embodies the research progress on endophytic microorganisms for producing bioactive enzyme inhibitors and their possible use in pharmaceutical industries. © Springer Nature Singapore Pte Ltd. 2018.

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