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פותח על ידי קלירמאש פתרונות בע"מ -
Recovery of visual function following gene therapy in a large animal model of CNGA3 achromatopsia
Year:
2013
Authors :
גוטויין, אלישע
;
.
הניג, חן
;
.
רוזוב, אלכסנדר
;
.
Volume :
54
Co-Authors:
Edward Averbukh, Esther Yamin, Alexey Obolensky, Eyal Banin - Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Ron Ofri, Raaya Ezra-Elia - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
William Hauswirth - Department of Ophthalmology, University of Florida, Gainesville, FL
Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

PurposeRecently, we reported on novel hereditary dayblindness in sheep caused by a mutation in the CNGA3 gene (Reicher et al., Genomics 95:101-104, 2010). Since mutations in this gene can also cause achromatopsia in humans, we decided to use these sheep as a cone-enriched, large animal model to evaluate safety and efficacy of CNGA3 gene therapy.

Note:
Related Files :
electroretinography
Electroretinography (ERG)
gene therapy
gene transfer
non-clinical
retinal degenerations: hereditary
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
0
Affiliations:
Database:
גוגל סקולר
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
43827
Last updated date:
02/03/2022 17:27
Creation date:
09/09/2019 13:11
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Scientific Publication
Recovery of visual function following gene therapy in a large animal model of CNGA3 achromatopsia
54
Edward Averbukh, Esther Yamin, Alexey Obolensky, Eyal Banin - Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Ron Ofri, Raaya Ezra-Elia - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
William Hauswirth - Department of Ophthalmology, University of Florida, Gainesville, FL
Recovery of visual function following gene therapy in a large animal model of CNGA3 achromatopsia

PurposeRecently, we reported on novel hereditary dayblindness in sheep caused by a mutation in the CNGA3 gene (Reicher et al., Genomics 95:101-104, 2010). Since mutations in this gene can also cause achromatopsia in humans, we decided to use these sheep as a cone-enriched, large animal model to evaluate safety and efficacy of CNGA3 gene therapy.

Scientific Publication
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