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פותח על ידי קלירמאש פתרונות בע"מ -
The "entourage effect": Terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders
Year:
2019
Source of publication :
Current Neuropharmacology
Authors :
נמדר, דבורי
;
.
קולטאי, חננית
;
.
Volume :
Co-Authors:

 Sari Goldstein Ferber, Danielle Hen-Shoval , Aron Weller - Psychology Department, Bar-Ilan University, Ramat Gan, Israel 

  Gilad Eger , Gal Shoval , Liat Shbiro   -  Geha Mental Health Center, Petah Tiqva, Israel

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Mood disorders are the most prevalent mental conditions encountered in psychiatric practice. Numerous patients suffering from mood disorders present with treatment-resistant forms of depression, co-morbid anxiety, other psychiatric disorders and bipolar disorders. Standardized essential oils (such as that of Lavender officinalis) have been shown to exert clinical efficacy in treating anxiety disorders. As endocannabinoids are suggested to play an important role in major depression, generalized anxiety and bipolar disorders, Cannabis sativa, was suggested for their treatment. The endocannabinoid system is widely distributed throughout the body including the brain, modulating many functions. It is involved in mood and related disorders, and its activity may be modified by exogenous cannabinoids. CB1 and CB2 receptors primarily serve as the binding sites for endocannabinoids as well as for phytocannabinoids, produced by cannabis inflorescences. However, 'cannabis' is not a single compound product but is known for its complicated molecular profile, producing a plethora of phytocannabinoids alongside a vast array of terpenes. Thus, the "entourage effect" is the suggested positive contribution derived from the addition of terpenes to cannabinoids. Here we review the literature on the effects of cannabinoids and discuss the possibility of enhancing cannabinoid activity on psychiatric symptoms by the addition of terpenes and terpenoids. Possible underlying mechanisms for the anti-depressant and anxiolytic effects are reviewed. These natural products may be an important potential source for new medications for the treatment of mood and anxiety disorders.

Note:
Related Files :
Cannabinoids
Disorder
lavender oil
mental disease
terpenes
Treatment
עוד תגיות
תוכן קשור
More details
DOI :
10.2174/1570159X17666190903103923
Article number:
0
Affiliations:
Database:
PubMed
Publication Type:
תקציר
;
.
Language:
אנגלית
Editors' remarks:
ID:
43857
Last updated date:
02/03/2022 17:27
Creation date:
11/09/2019 14:32
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Scientific Publication
The "entourage effect": Terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders

 Sari Goldstein Ferber, Danielle Hen-Shoval , Aron Weller - Psychology Department, Bar-Ilan University, Ramat Gan, Israel 

  Gilad Eger , Gal Shoval , Liat Shbiro   -  Geha Mental Health Center, Petah Tiqva, Israel

The "entourage effect": Terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders

Mood disorders are the most prevalent mental conditions encountered in psychiatric practice. Numerous patients suffering from mood disorders present with treatment-resistant forms of depression, co-morbid anxiety, other psychiatric disorders and bipolar disorders. Standardized essential oils (such as that of Lavender officinalis) have been shown to exert clinical efficacy in treating anxiety disorders. As endocannabinoids are suggested to play an important role in major depression, generalized anxiety and bipolar disorders, Cannabis sativa, was suggested for their treatment. The endocannabinoid system is widely distributed throughout the body including the brain, modulating many functions. It is involved in mood and related disorders, and its activity may be modified by exogenous cannabinoids. CB1 and CB2 receptors primarily serve as the binding sites for endocannabinoids as well as for phytocannabinoids, produced by cannabis inflorescences. However, 'cannabis' is not a single compound product but is known for its complicated molecular profile, producing a plethora of phytocannabinoids alongside a vast array of terpenes. Thus, the "entourage effect" is the suggested positive contribution derived from the addition of terpenes to cannabinoids. Here we review the literature on the effects of cannabinoids and discuss the possibility of enhancing cannabinoid activity on psychiatric symptoms by the addition of terpenes and terpenoids. Possible underlying mechanisms for the anti-depressant and anxiolytic effects are reviewed. These natural products may be an important potential source for new medications for the treatment of mood and anxiety disorders.

Scientific Publication
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